NOC4L_MOUSE
ID NOC4L_MOUSE Reviewed; 516 AA.
AC Q8BHY2; Q8R1F7;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Nucleolar complex protein 4 homolog;
DE Short=NOC4 protein homolog;
DE AltName: Full=NOC4-like protein;
DE AltName: Full=Nucleolar complex-associated protein 4-like protein;
GN Name=Noc4l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9BVI4};
CC Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9BVI4}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR EMBL; AK052601; BAC35057.1; -; mRNA.
DR EMBL; BC024616; AAH24616.1; -; mRNA.
DR CCDS; CCDS19527.1; -.
DR RefSeq; NP_705798.2; NM_153570.2.
DR AlphaFoldDB; Q8BHY2; -.
DR SMR; Q8BHY2; -.
DR BioGRID; 221496; 2.
DR STRING; 10090.ENSMUSP00000038263; -.
DR PhosphoSitePlus; Q8BHY2; -.
DR EPD; Q8BHY2; -.
DR MaxQB; Q8BHY2; -.
DR PaxDb; Q8BHY2; -.
DR PeptideAtlas; Q8BHY2; -.
DR PRIDE; Q8BHY2; -.
DR ProteomicsDB; 293868; -.
DR Antibodypedia; 19475; 91 antibodies from 27 providers.
DR DNASU; 100608; -.
DR Ensembl; ENSMUST00000042147; ENSMUSP00000038263; ENSMUSG00000033294.
DR GeneID; 100608; -.
DR KEGG; mmu:100608; -.
DR UCSC; uc008yrd.1; mouse.
DR CTD; 79050; -.
DR MGI; MGI:2140843; Noc4l.
DR VEuPathDB; HostDB:ENSMUSG00000033294; -.
DR eggNOG; KOG2154; Eukaryota.
DR GeneTree; ENSGT00390000016776; -.
DR HOGENOM; CLU_015945_3_0_1; -.
DR InParanoid; Q8BHY2; -.
DR OMA; DVRYYTF; -.
DR OrthoDB; 891751at2759; -.
DR PhylomeDB; Q8BHY2; -.
DR TreeFam; TF105812; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 100608; 22 hits in 77 CRISPR screens.
DR PRO; PR:Q8BHY2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BHY2; protein.
DR Bgee; ENSMUSG00000033294; Expressed in primary oocyte and 267 other tissues.
DR Genevisible; Q8BHY2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR027193; Noc4.
DR PANTHER; PTHR12455; PTHR12455; 1.
DR Pfam; PF03914; CBF; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..516
FT /note="Nucleolar complex protein 4 homolog"
FT /id="PRO_0000173485"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 407
FT /note="R -> H (in Ref. 2; AAH24616)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 516 AA; 58676 MW; 4F8787885A3BA569 CRC64;
MERHPASASS RQELGRLLEA VLTSRGQANA VFDILAVLQS EEPEEIEEGV RTCSRLFGTL
LEREELFVGS LPSEDTALAG SQGATYKYKV WIRHRYHSCC NRLEELLAHP TFQVKELALK
TLMKFVQLEG AKPLEKPQWE SHYLFPRTLF RAVVGGLLTP EDDHSLLISH FCEYLEYDDI
RYHTMQVATS IMARATSQQP EVSLTLWNNA FTLLSAVSLP LQECELTNFY VKHAQTSDKW
KVVHLKEHKK AFQEMWLGFL KHKLPLSLYK KVLVAMHDSI LPHLAQPTLM IDFLTSACDV
GGAISLLALN GLFILIHKHN LEYPDFYQKL YGLLDPSIFH VKYRARFFHL ADLFLSSSHL
PAYLVAAFAK RLARLALTAP PEALLMVLPL ICNLLRRHPA CRVMVHRPQG PELDADPYDP
TEKDPARSRA LESCLWELQT LQQHYHPEVS KAASVINQVL SVPEVSIAPL LELTAYEIFE
QDLKKKMPES VPLEFIPAKG LLGRQDDLCT QFFCLS
