ID   NOC4L_RAT               Reviewed;         516 AA.
AC   Q5I0I8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Nucleolar complex protein 4 homolog;
DE            Short=NOC4 protein homolog;
DE   AltName: Full=NOC4-like protein;
DE   AltName: Full=Nucleolar complex-associated protein 4-like protein;
GN   Name=Noc4l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9BVI4};
CC       Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9BVI4}.
CC   -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
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DR   EMBL; BC088275; AAH88275.1; -; mRNA.
DR   RefSeq; NP_001014151.1; NM_001014129.1.
DR   AlphaFoldDB; Q5I0I8; -.
DR   SMR; Q5I0I8; -.
DR   STRING; 10116.ENSRNOP00000053566; -.
DR   iPTMnet; Q5I0I8; -.
DR   PhosphoSitePlus; Q5I0I8; -.
DR   PaxDb; Q5I0I8; -.
DR   PRIDE; Q5I0I8; -.
DR   GeneID; 360828; -.
DR   KEGG; rno:360828; -.
DR   UCSC; RGD:1310661; rat.
DR   CTD; 79050; -.
DR   RGD; 1310661; Noc4l.
DR   VEuPathDB; HostDB:ENSRNOG00000037478; -.
DR   eggNOG; KOG2154; Eukaryota.
DR   HOGENOM; CLU_015945_3_0_1; -.
DR   InParanoid; Q5I0I8; -.
DR   OMA; DVRYYTF; -.
DR   OrthoDB; 891751at2759; -.
DR   PhylomeDB; Q5I0I8; -.
DR   TreeFam; TF105812; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q5I0I8; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000037478; Expressed in pancreas and 19 other tissues.
DR   Genevisible; Q5I0I8; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR005612; CCAAT-binding_factor.
DR   InterPro; IPR027193; Noc4.
DR   PANTHER; PTHR12455; PTHR12455; 1.
DR   Pfam; PF03914; CBF; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..516
FT                   /note="Nucleolar complex protein 4 homolog"
FT                   /id="PRO_0000173486"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   516 AA;  58862 MW;  1D11D524C58510EA CRC64;
     MERQPASTGS RQELGRLLEA VLSNRGRANA VFDILAVLQS EDPEEIKEGV RTCSRLFGTL
     LEREELFVGS LPCEDMALAG SQGATYKYKV WMRHRYHSCC NRLEELLTHP SFQVKELALE
     TLMKFVQLEG AKPLEKPQWE SHYLFPRTLF RAVVGGLLTP EDDHSLLISQ FCEYLEYDDI
     RYHAMQVATS ILARATSRQP EVSLTFWNNA FTLLSAVNLP LQEHELTNFY VKHAQTSSKW
     KVVHLKEQRK AFQEMWLGFL KHKLPLSLYK KVLVAMHDSI LPHLAQPTLM IDFLTSACDV
     GGAISLLALN GLFILIHKHN LEYPDFYQRL YGLLDPSIFH VKYRARFFHL ADLFLSSSHL
     PAYLVAAFAK RLARLALTAP PEALLMVLPL ICNLLRRHPA CRVMVHRPQG PELDADPYDP
     TEKDPARSRA LESCLWELQT LQQHYHPEVS RAASVINQAL SVPEVSIAPL LELTAYEIFE
     QDLKKMMPES VPLEFIPAKG LLGRQDDLCT QFFCLS