NOC4_ARATH
ID NOC4_ARATH Reviewed; 577 AA.
AC F4IMH3; O22737; Q8VZE1;
DT 11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Protein NUCLEOLAR COMPLEX ASSOCIATED 4 {ECO:0000303|PubMed:23382868};
DE Short=AtNoc4 {ECO:0000303|PubMed:23382868};
DE AltName: Full=Protein EMBRYO DEFECTIVE 2762 {ECO:0000303|PubMed:15266054};
GN Name=NOC4 {ECO:0000303|PubMed:23382868};
GN Synonyms=EMB2762 {ECO:0000303|PubMed:15266054};
GN OrderedLocusNames=At2g17250 {ECO:0000312|Araport:AT2G17250};
GN ORFNames=T23A1.11 {ECO:0000312|EMBL:AAM15399.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION [LARGE SCALE ANALYSIS], AND DISRUPTION PHENOTYPE [LARGE SCALE
RP ANALYSIS].
RC STRAIN=cv. Columbia;
RX PubMed=15266054; DOI=10.1104/pp.104.045179;
RA Tzafrir I., Pena-Muralla R., Dickerman A., Berg M., Rogers R., Hutchens S.,
RA Sweeney T.C., McElver J., Aux G., Patton D., Meinke D.;
RT "Identification of genes required for embryo development in Arabidopsis.";
RL Plant Physiol. 135:1206-1220(2004).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=23382868; DOI=10.1371/journal.pone.0054084;
RA Missbach S., Weis B.L., Martin R., Simm S., Bohnsack M.T., Schleiff E.;
RT "40S ribosome biogenesis co-factors are essential for gametophyte and
RT embryo development.";
RL PLoS ONE 8:E54084-E54084(2013).
CC -!- FUNCTION: Essential protein required during embryogenesis
CC (PubMed:15266054, PubMed:23382868). Involved in nucleolar processing of
CC ribosomal RNA (rRNA) 40S and 90S ribosomal subunits and ribosome
CC assembly; early in ribosome biogenesis, especially required during the
CC maturation of 5.8S rRNA (PubMed:23382868). Has a role in the nuclear
CC export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
CC {ECO:0000250|UniProtKB:Q06512, ECO:0000269|PubMed:15266054,
CC ECO:0000269|PubMed:23382868}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC composed of at least 40 protein subunits and snoRNA U3.
CC {ECO:0000250|UniProtKB:Q06512}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9BVI4};
CC Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus
CC {ECO:0000269|PubMed:23382868}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and stems and at lower
CC levels in roots, hypocotyls, siliques, leaves and seeds.
CC {ECO:0000269|PubMed:23382868}.
CC -!- DISRUPTION PHENOTYPE: Pale seeds with arrested embryo development at
CC the globular stage in homozygous plants (PubMed:15266054,
CC PubMed:23382868). In heterozygous plants, slight accumulation of the
CC 23S-like precursor P-A3 (PubMed:23382868). Altered maturation of 5.8S
CC rRNA with an especially impaired processing at the 5' end
CC (PubMed:23382868). {ECO:0000269|PubMed:15266054,
CC ECO:0000269|PubMed:23382868}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM15399.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Seed defective Arabidopsis mutants;
CC URL="http://seedgenes.org/MutantList";
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DR EMBL; AC007127; AAM15399.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06603.1; -; Genomic_DNA.
DR EMBL; AY065021; AAL57663.1; -; mRNA.
DR PIR; H84549; H84549.
DR RefSeq; NP_179316.2; NM_127279.3.
DR AlphaFoldDB; F4IMH3; -.
DR SMR; F4IMH3; -.
DR STRING; 3702.AT2G17250.1; -.
DR PaxDb; F4IMH3; -.
DR PRIDE; F4IMH3; -.
DR ProteomicsDB; 212585; -.
DR EnsemblPlants; AT2G17250.1; AT2G17250.1; AT2G17250.
DR GeneID; 816230; -.
DR Gramene; AT2G17250.1; AT2G17250.1; AT2G17250.
DR KEGG; ath:AT2G17250; -.
DR Araport; AT2G17250; -.
DR TAIR; locus:2059657; AT2G17250.
DR eggNOG; KOG2154; Eukaryota.
DR HOGENOM; CLU_015945_1_0_1; -.
DR InParanoid; F4IMH3; -.
DR OMA; PGIDHFN; -.
DR OrthoDB; 891751at2759; -.
DR PRO; PR:F4IMH3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IMH3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030692; C:Noc4p-Nop14p complex; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0005654; C:nucleoplasm; IDA:TAIR.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0006364; P:rRNA processing; IMP:TAIR.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR027193; Noc4.
DR PANTHER; PTHR12455; PTHR12455; 1.
DR Pfam; PF03914; CBF; 1.
PE 2: Evidence at transcript level;
KW Membrane; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT CHAIN 1..577
FT /note="Protein NUCLEOLAR COMPLEX ASSOCIATED 4"
FT /id="PRO_0000448723"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 230..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 347
FT /note="Q -> R (in Ref. 3; AAL57663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 577 AA; 65348 MW; 75F0A9D5F99FA25F CRC64;
MASILSKKQK KNEKYTLKEL KSLGHDLLTS RSHINNLPLL LTFVSPESPP QFVVESLLSL
QSFFTPLLSQ LPPTSSSPSS TKTEDPEVVF KAWLRSKFDE FVKLLLDVLV SQQSEDSLRG
IVLGTLMEFV KLLNAGRFHS SIYHRLLDAI IHSEVDIEIF LDILTSKYFK YIDVRYFTYI
SMEKFVKTLE ASVSADRTVI ENNEAESDSK ESLELSVRKI YQVLSQIPPP EKQAEKSQHE
MWSGSDESIS EKPTDKKKKT EKGDSTLLSP ATISKRMKLK FTKAWISFLR LPLPIDVYKE
VLASIHLTVI PHLSNPTMLC DFLTKSYDIG GVVSVMALSS LFILMTQHGL EYPFFYEKLY
ALLVPSVFVA KHRAKFLQLL DACLKSSMLP AYLAASFTKK LSRLSLSIPP AGSLVITALI
YNLLRRNPTI NHLVQEIVEN ADEANTEAGE HNESQPKTIK KRKLGIDYFN NQESDPKKSG
ALKSSLWEID TLRHHYCPPV SRFISSLETN LTIRSKTTEM KIEDFCSGSY ATIFGDEIRR
RVKQVPLAFY KTVPTSLFAD SDFPGWTFTI PQEEGTC
