NOCA1_CAEEL
ID NOCA1_CAEEL Reviewed; 922 AA.
AC G5EEK3; A0A0M3UPV7; G5EBN2; G5EBP7; G5EC74; G5EE58; N1NSE8; Q8I4G1; Q9XVL5;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Non-centrosomal microtubule array protein 1 {ECO:0000312|WormBase:T09E8.1c};
GN Name=noca-1 {ECO:0000312|WormBase:T09E8.1c};
GN ORFNames=T09E8.1 {ECO:0000312|WormBase:T09E8.1c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H), FUNCTION, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=26371552; DOI=10.7554/elife.08649;
RA Wang S., Wu D., Quintin S., Green R.A., Cheerambathur D.K., Ochoa S.D.,
RA Desai A., Oegema K.;
RT "NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to
RT assemble non-centrosomal microtubule arrays in C. elegans.";
RL Elife 4:E08649-E08649(2015).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=26586219; DOI=10.1242/dev.126615;
RA Quintin S., Wang S., Pontabry J., Bender A., Robin F., Hyenne V.,
RA Landmann F., Gally C., Oegema K., Labouesse M.;
RT "Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to
RT promote C. elegans elongation.";
RL Development 143:160-173(2016).
CC -!- FUNCTION: Plays a role in the assembly of microtubule arrays in the
CC germline acting redundantly with ptrn-1 to control circumferential
CC microtubule assembly along the body which is necessary for larval
CC development, viability, and morphology and integrity of the epidermis
CC (PubMed:26371552). Required for microtubule stability and anchorage by
CC binding to microtubule minus ends (PubMed:26371552). Recruited to
CC hemidesomosomes in early embryonic elongation to direct the nucleation
CC and growth of non-centrosomal microtubules (PubMed:26586219).
CC {ECO:0000269|PubMed:26371552, ECO:0000269|PubMed:26586219}.
CC -!- FUNCTION: [Isoform b]: Required for normal nuclear migration in the
CC embryonic epidermis. {ECO:0000269|PubMed:26371552}.
CC -!- FUNCTION: [Isoform h]: Directs the assembly of non-centrosomal
CC microtubule arrays that determine the position of nuclei within
CC intracellular compartments in the epidermis and this is independent of
CC ptrn-1 activity. {ECO:0000269|PubMed:26371552}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:26371552}. Apical cell membrane
CC {ECO:0000269|PubMed:26371552}. Cell junction, hemidesmosome
CC {ECO:0000269|PubMed:26586219}. Cell junction, adherens junction
CC {ECO:0000269|PubMed:26586219}. Note=Isoform h: Co-localizes with gamma-
CC tubulin to the apical cell membrane. {ECO:0000269|PubMed:26371552}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=c {ECO:0000312|WormBase:T09E8.1c};
CC IsoId=G5EEK3-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:T09E8.1a};
CC IsoId=G5EEK3-2; Sequence=VSP_058278;
CC Name=b {ECO:0000312|WormBase:T09E8.1b};
CC IsoId=G5EEK3-3; Sequence=VSP_058279;
CC Name=d {ECO:0000312|WormBase:T09E8.1d};
CC IsoId=G5EEK3-4; Sequence=VSP_058274;
CC Name=e {ECO:0000312|WormBase:T09E8.1e};
CC IsoId=G5EEK3-5; Sequence=VSP_058275;
CC Name=f {ECO:0000312|WormBase:T09E8.1f};
CC IsoId=G5EEK3-6; Sequence=VSP_058280;
CC Name=g {ECO:0000312|WormBase:T09E8.1g};
CC IsoId=G5EEK3-7; Sequence=VSP_058276;
CC Name=h {ECO:0000312|WormBase:T09E8.1h};
CC IsoId=G5EEK3-8; Sequence=VSP_058281;
CC Name=i {ECO:0000312|WormBase:T09E8.1i};
CC IsoId=G5EEK3-9; Sequence=VSP_058277, VSP_058282;
CC -!- DEVELOPMENTAL STAGE: First expressed in between seam cells at the lima-
CC bean stage of embryogenesis (PubMed:26586219). Expressed in the
CC embryonic epidermis and in puncta in the epidermal syncytium and also
CC in between the epidermal body syncytium and the seam cells of larvae
CC (PubMed:26371552). {ECO:0000269|PubMed:26371552,
CC ECO:0000269|PubMed:26586219}.
CC -!- DISRUPTION PHENOTYPE: [Isoform b]: Deletion results in slower embryonic
CC development, mutants that are 5% shorter than their wild-type
CC conterparts, and also leads to the prevention of nuclear migration in
CC the embryonic epidermis (PubMed:26371552, PubMed:26586219). RNAi-
CC mediated knockdown results in fragmentation of the cadherin-based
CC junctional complex in embryos and intermediate filaments display a
CC diffuse pattern in older embryos (PubMed:26586219). RNAi-mediated
CC knockdown of isoform h results in disrupted germline architecture and
CC sterility (PubMed:26371552). {ECO:0000269|PubMed:26371552,
CC ECO:0000269|PubMed:26586219}.
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DR EMBL; KT722731; ALF12299.1; -; mRNA.
DR EMBL; BX284605; CAB03162.1; -; Genomic_DNA.
DR EMBL; BX284605; CAB54298.2; -; Genomic_DNA.
DR EMBL; BX284605; CAB54297.2; -; Genomic_DNA.
DR EMBL; BX284605; CAD54154.1; -; Genomic_DNA.
DR EMBL; BX284605; CAD54155.2; -; Genomic_DNA.
DR EMBL; BX284605; CAD54156.2; -; Genomic_DNA.
DR EMBL; BX284605; CAJ80826.1; -; Genomic_DNA.
DR EMBL; BX284605; CCW45976.1; -; Genomic_DNA.
DR EMBL; BX284605; CUR30005.1; -; Genomic_DNA.
DR PIR; T23293; T23293.
DR PIR; T23295; T23295.
DR PIR; T23296; T23296.
DR RefSeq; NP_001041165.1; NM_001047700.2. [G5EEK3-6]
DR RefSeq; NP_001294691.1; NM_001307762.1.
DR RefSeq; NP_001303706.1; NM_001316777.1. [G5EEK3-8]
DR RefSeq; NP_506274.1; NM_073873.1. [G5EEK3-9]
DR RefSeq; NP_506275.2; NM_073874.4. [G5EEK3-3]
DR RefSeq; NP_506276.2; NM_073875.4. [G5EEK3-2]
DR RefSeq; NP_872199.2; NM_182399.5. [G5EEK3-1]
DR RefSeq; NP_872200.1; NM_182400.4. [G5EEK3-4]
DR RefSeq; NP_872201.2; NM_182401.2. [G5EEK3-5]
DR AlphaFoldDB; G5EEK3; -.
DR SMR; G5EEK3; -.
DR IntAct; G5EEK3; 3.
DR STRING; 6239.T09E8.1c; -.
DR EPD; G5EEK3; -.
DR PaxDb; G5EEK3; -.
DR PeptideAtlas; G5EEK3; -.
DR EnsemblMetazoa; T09E8.1a.1; T09E8.1a.1; WBGene00011647. [G5EEK3-2]
DR EnsemblMetazoa; T09E8.1b.1; T09E8.1b.1; WBGene00011647. [G5EEK3-3]
DR EnsemblMetazoa; T09E8.1c.1; T09E8.1c.1; WBGene00011647. [G5EEK3-1]
DR EnsemblMetazoa; T09E8.1d.1; T09E8.1d.1; WBGene00011647. [G5EEK3-4]
DR EnsemblMetazoa; T09E8.1e.1; T09E8.1e.1; WBGene00011647. [G5EEK3-5]
DR EnsemblMetazoa; T09E8.1f.1; T09E8.1f.1; WBGene00011647. [G5EEK3-6]
DR EnsemblMetazoa; T09E8.1g.1; T09E8.1g.1; WBGene00011647. [G5EEK3-7]
DR EnsemblMetazoa; T09E8.1h.1; T09E8.1h.1; WBGene00011647. [G5EEK3-8]
DR EnsemblMetazoa; T09E8.1i.1; T09E8.1i.1; WBGene00011647. [G5EEK3-9]
DR GeneID; 3565610; -.
DR KEGG; cel:CELE_T09E8.1; -.
DR UCSC; K03H4.2; c. elegans.
DR UCSC; T09E8.1c; c. elegans.
DR CTD; 3565610; -.
DR WormBase; T09E8.1a; CE31987; WBGene00011647; noca-1. [G5EEK3-2]
DR WormBase; T09E8.1b; CE31988; WBGene00011647; noca-1. [G5EEK3-3]
DR WormBase; T09E8.1c; CE41451; WBGene00011647; noca-1. [G5EEK3-1]
DR WormBase; T09E8.1d; CE31990; WBGene00011647; noca-1. [G5EEK3-4]
DR WormBase; T09E8.1e; CE47381; WBGene00011647; noca-1. [G5EEK3-5]
DR WormBase; T09E8.1f; CE39958; WBGene00011647; noca-1. [G5EEK3-6]
DR WormBase; T09E8.1g; CE48378; WBGene00011647; noca-1. [G5EEK3-7]
DR WormBase; T09E8.1h; CE51088; WBGene00011647; noca-1. [G5EEK3-8]
DR WormBase; T09E8.1i; CE11698; WBGene00011647; noca-1. [G5EEK3-9]
DR eggNOG; ENOG502SSZU; Eukaryota.
DR InParanoid; G5EEK3; -.
DR OMA; QNRATPI; -.
DR OrthoDB; 1658778at2759; -.
DR PRO; PR:G5EEK3; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011647; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030056; C:hemidesmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IDA:WormBase.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IGI:WormBase.
DR GO; GO:0007281; P:germ cell development; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IGI:WormBase.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell junction; Cell membrane; Coiled coil; Cytoplasm;
KW Cytoskeleton; Membrane; Reference proteome.
FT CHAIN 1..922
FT /note="Non-centrosomal microtubule array protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000436174"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 564..728
FT /evidence="ECO:0000255"
FT COMPBIAS 22..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..456
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQ
FT RVRSYNNSQFQASDLSLNPNGSIRAACDSTSGSVAPTAVVNPARNHVISHRQQHHTSYE
FT KDLIPHHNIDVDRRRSLQALNGSSALYQLNNGGSPNGVRSQFSPSDLSIHTPVHHVGSR
FT VRVSSVNQICDSNSAPQFSIDQRRSVHNIGNPVRNSFVDGIKTTSTPKNQ -> MNICC
FT CGGAMGRFYTKMIERLTGGGSPTSDQNGNSHHHHHHLPPAPRHLSSSHHQIETISGSSK
FT LRAQSGSPALNRKKRPE (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058274"
FT VAR_SEQ 1..427
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQ
FT RVRSYNNSQFQASDLSLNPNGSIRAACDSTSGSVAPTAVVNPARNHVISHRQQHHTSYE
FT KDLIPHHNIDVDRRRSLQALNGSSALYQLNNGGSPNGVRSQFSPSDLSIHTPVHHVGSR
FT VRVSSVNQICDSNSAPQFSID -> MSLVSGKTESSARWSIRPSCSCNDSLFTISDTEC
FT SEIEADMRRKDRHNWKKS (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_058275"
FT VAR_SEQ 1..370
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQ
FT RVRSYNNSQFQASDLSLNPNGSIRAACDSTSGSVAPTAVVNPARNHVISHRQQHHTSYE
FT KDLIPHHNIDVDRRRSLQALNGS -> MQSIREPRSVELRESNKFMRSISHGRASTWRR
FT NRIRPDNQLSA (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_058276"
FT VAR_SEQ 1..264
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDA -> MLKQLLALTCMHKKDKNKLA
FT ITAGTAECSNRSPQNSPGSSSEGAADESLNQSVAIPEEAHLNTSQFISLPLSDVSFEAA
FT ASQNRATPIDFGTREVKEDDDVLSDTGRRRSVNLITPSPIPEETEDNLTETPIPVVEHI
FT PRSAIFEPFNHENSPLFSVKARKKAHEYRSNDSTLSPSSSSNNDDSIRIDSIRVRSSKS
FT ATNNQLKGRLTPILGGSLRPIPKKRNRVAFNGNSTFVAPERLCLEVDKIHQDRCRFSFV
FT LTLCVPYA (in isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058277"
FT VAR_SEQ 1..251
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSPV -> MCLVCAGCKVLSTLRAYCTGFMPNITVIIAPKK
FT VLTSNSSSSTSDISMHRSIPEIYVPNDKYNEEKPIRRKSHGNI (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_058278"
FT VAR_SEQ 1..250
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSP -> MASLCNSIIGWIKNDKE (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058279"
FT VAR_SEQ 1..250
FT /note="MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDR
FT PKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNS
FT STPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLS
FT QRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFS
FT VDNRMSKYQKNQSLRQFLNSP -> MLQPPSPRLGKRNIIKNVT (in isoform
FT f)"
FT /evidence="ECO:0000305"
FT /id="VSP_058280"
FT VAR_SEQ 2..251
FT /note="SNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDRP
FT KYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNSS
FT TPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLSQ
FT RRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFSV
FT DNRMSKYQKNQSLRQFLNSPV -> LKQLLALTCMHKKDKNKLAITAGTAECSNRSPQN
FT SPGSSSEGAADESLNQSVAIPEEAHLNTSQFISLPLSDVSFEAAASQNRATPIDFGTRE
FT VKEDDDVLSDTGRRRSVNLITPSPIPEETEDNLTETPIPVVEHIPRSAIFEPFNHENSP
FT LFSVKARKKAHEYRSNDSTLSPSSSSNNDDSIRIDSIRVRSSKSATNNQLKGRLTPILG
FT GSLRPIPKKRNRVAFNGNSTFVAPERLCLEVDKIHQDRF (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_058281"
FT VAR_SEQ 265..922
FT /note="Missing (in isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058282"
SQ SEQUENCE 922 AA; 103684 MW; 920C15936BAEDC1B CRC64;
MSNERVSTGS LGERLMLRTR STRGSVRETL SKAIRSTLGR ASSMERKDMP DRPKYGTALT
AMTSTTPPSP KDRSSDSGDG DSPRPRKFSS KECARIYFSN TSSEHSSRSN SSTPRRVRHT
TASSGYGSLS HLPPISYRKS SDPLNSLMSQ SMYVQSPGMH IDEPKCTSLS QRRLYYEDSS
ETYIPSSPSL TTLKDFMMTN DDETFDDFDF DNDDVKSVIS SASTSRIFSV DNRMSKYQKN
QSLRQFLNSP VRLRKRGDTS RRDAVEAGFE PRDTVPRCHS TQSLRDVQRV RSYNNSQFQA
SDLSLNPNGS IRAACDSTSG SVAPTAVVNP ARNHVISHRQ QHHTSYEKDL IPHHNIDVDR
RRSLQALNGS SALYQLNNGG SPNGVRSQFS PSDLSIHTPV HHVGSRVRVS SVNQICDSNS
APQFSIDQRR SVHNIGNPVR NSFVDGIKTT STPKNQIAVA PLAHKSRHLS ESRDEMRGGA
ERRGSGGQMN LPAYTNYLIR HSGEERLVDG PVTNASDARI AYLEKRIREL ELTQKEQSSH
STPSQSRHSS SKSSHFNGSS NLSTSEQLRL QEMSDELANK DRKVTSLESK LLKAYQRIER
LNEEYDGKIK NLMYDSERAR DDLTRCVDKI QQLENELDET RAAVQNGDHA NEQEYHELRD
KIWKQERELQ ESRTLLTRLR EKEAEFERMR SEKGYLELKN ENLNKKLEAK KRAVEELERS
VSTLRLEQTI CQQSCSSGST PLADEMEIMS DIRPSLARPY TKAHSTLGSH NMSPLSHSKS
SGLTKSFSNF ALNSSKQRDD ITANMSRSIR EQNRHITMCR AMVVCLKDTV DRMARGENPD
VARLLGVKLN VMSESEMEDD EDHEADASQP FSMMSAESAL SKQCGKLADL DKDLDTIRCQ
LADWHGQTNA EGDGDRDVCR VQ
