NOC_BACAN
ID NOC_BACAN Reviewed; 290 AA.
AC Q81JH5; Q6HQ17; Q6KJG1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN Name=noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN OrderedLocusNames=BA_5731, GBAA_5731, BAS5334;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
CC -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC nonspecifically to DNA and preventing the assembly of the division
CC machinery in the vicinity of the nucleoid, especially under conditions
CC that disturb the cell cycle. It helps to coordinate cell division and
CC chromosome segregation by preventing the formation of the Z ring
CC through the nucleoid, which would cause chromosome breakage.
CC {ECO:0000255|HAMAP-Rule:MF_02015}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_02015}.
CC -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC Rule:MF_02015}.
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DR EMBL; AE016879; AAP29362.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT34891.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT57621.1; -; Genomic_DNA.
DR RefSeq; NP_847876.1; NC_003997.3.
DR RefSeq; WP_000799028.1; NZ_WXXJ01000028.1.
DR RefSeq; YP_031571.1; NC_005945.1.
DR AlphaFoldDB; Q81JH5; -.
DR SMR; Q81JH5; -.
DR STRING; 260799.BAS5334; -.
DR DNASU; 1085499; -.
DR EnsemblBacteria; AAP29362; AAP29362; BA_5731.
DR EnsemblBacteria; AAT34891; AAT34891; GBAA_5731.
DR GeneID; 45025309; -.
DR KEGG; ban:BA_5731; -.
DR KEGG; bar:GBAA_5731; -.
DR KEGG; bat:BAS5334; -.
DR PATRIC; fig|198094.11.peg.5692; -.
DR eggNOG; COG1475; Bacteria.
DR HOGENOM; CLU_023853_0_1_9; -.
DR OMA; SQSYVAN; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR HAMAP; MF_02015; ParB_Noc; 1.
DR InterPro; IPR041468; HTH_ParB/Spo0J.
DR InterPro; IPR023705; Nucleoid_occlusion_protein.
DR InterPro; IPR004437; ParB/RepB/Spo0J.
DR InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR Pfam; PF17762; HTH_ParB; 1.
DR Pfam; PF02195; ParBc; 1.
DR SMART; SM00470; ParB; 1.
DR SUPFAM; SSF110849; SSF110849; 1.
DR TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR TIGRFAMs; TIGR00180; parB_part; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; DNA-binding; Reference proteome;
KW Septation.
FT CHAIN 1..290
FT /note="Nucleoid occlusion protein"
FT /id="PRO_0000346617"
FT DNA_BIND 153..172
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ SEQUENCE 290 AA; 33617 MW; C5931D4C9E9467FF CRC64;
MKNTFSRLFG FGDKESEFEL QDESHEEIDK KVYEEIQEIP IVNITPNRYQ PRTVFDDARI
EELALTIRTH GLIQPIVVRQ YEDDKYEIIA GERRFRAATK LGWEKVPAII KNLNDTETAS
VALIENLQRE ELTAIEEAVA YQKLIELHNL TQEALAQRLG KGQSTIANKL RLLKLPEEIK
SALLEKSITE RHARALIPLK NEELQLKVLQ EIVEKQLNVK QTEERITKLL EEAKPKRKAK
QKAVSRDTRI AMNTIRQSLQ MVADSGLNVN SEEEEFDEYY QITIQIPKKK
