ID   NOC_BACC4               Reviewed;         290 AA.
AC   B7HGE1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE            Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   Name=noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   OrderedLocusNames=BCB4264_A5608;
OS   Bacillus cereus (strain B4264).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405532;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4264;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus B4264.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC       nonspecifically to DNA and preventing the assembly of the division
CC       machinery in the vicinity of the nucleoid, especially under conditions
CC       that disturb the cell cycle. It helps to coordinate cell division and
CC       chromosome segregation by preventing the formation of the Z ring
CC       through the nucleoid, which would cause chromosome breakage.
CC       {ECO:0000255|HAMAP-Rule:MF_02015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
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DR   EMBL; CP001176; ACK61627.1; -; Genomic_DNA.
DR   RefSeq; WP_000799016.1; NZ_VEHB01000004.1.
DR   AlphaFoldDB; B7HGE1; -.
DR   SMR; B7HGE1; -.
DR   EnsemblBacteria; ACK61627; ACK61627; BCB4264_A5608.
DR   GeneID; 67510107; -.
DR   KEGG; bcb:BCB4264_A5608; -.
DR   HOGENOM; CLU_023853_0_1_9; -.
DR   OMA; SQSYVAN; -.
DR   Proteomes; UP000007096; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   HAMAP; MF_02015; ParB_Noc; 1.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR023705; Nucleoid_occlusion_protein.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Septation.
FT   CHAIN           1..290
FT                   /note="Nucleoid occlusion protein"
FT                   /id="PRO_1000189532"
FT   DNA_BIND        153..172
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ   SEQUENCE   290 AA;  33618 MW;  B3DE34F7E3F0390B CRC64;
     MKNTFSRLFG FGDKESEFEL QDESHEEIDK KVYEEIQEIP IVNITPNRYQ PRTVFDDARI
     DELALTIRTH GLIQPIVVRQ YEDDKYEIIA GERRFRAATK LGWEKVPAII KNLNDTETAS
     VALIENLQRE ELTAIEEAVA YQKLIELHNL TQEALAQRLG KGQSTIANKL RLLKLPEEIK
     SALLEKSITE RHARALIPLK NEELQLKVLQ EIVEKQLNVK QTEERIAKLL EEAKPKRKAK
     QKAVSRDTRI AMNTIRQSLQ MVTESGLNVN SEEEEFDEYY QITIKIPKKK