NOC_BACLD
ID NOC_BACLD Reviewed; 283 AA.
AC Q65CN4; Q62N63;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN Name=noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN OrderedLocusNames=BLi04372, BL00107;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC nonspecifically to DNA and preventing the assembly of the division
CC machinery in the vicinity of the nucleoid, especially under conditions
CC that disturb the cell cycle. It helps to coordinate cell division and
CC chromosome segregation by preventing the formation of the Z ring
CC through the nucleoid, which would cause chromosome breakage.
CC {ECO:0000255|HAMAP-Rule:MF_02015}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_02015}.
CC -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC Rule:MF_02015}.
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DR EMBL; CP000002; AAU25798.1; -; Genomic_DNA.
DR EMBL; AE017333; AAU43180.1; -; Genomic_DNA.
DR RefSeq; WP_003178042.1; NC_006322.1.
DR AlphaFoldDB; Q65CN4; -.
DR SMR; Q65CN4; -.
DR STRING; 279010.BL00107; -.
DR EnsemblBacteria; AAU25798; AAU25798; BL00107.
DR GeneID; 66213718; -.
DR KEGG; bld:BLi04372; -.
DR KEGG; bli:BL00107; -.
DR eggNOG; COG1475; Bacteria.
DR HOGENOM; CLU_023853_0_1_9; -.
DR OMA; SQSYVAN; -.
DR OrthoDB; 653368at2; -.
DR BioCyc; BLIC279010:BLI_RS21495-MON; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR HAMAP; MF_02015; ParB_Noc; 1.
DR InterPro; IPR041468; HTH_ParB/Spo0J.
DR InterPro; IPR023705; Nucleoid_occlusion_protein.
DR InterPro; IPR004437; ParB/RepB/Spo0J.
DR InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR Pfam; PF17762; HTH_ParB; 1.
DR Pfam; PF02195; ParBc; 1.
DR SMART; SM00470; ParB; 1.
DR SUPFAM; SSF110849; SSF110849; 1.
DR TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR TIGRFAMs; TIGR00180; parB_part; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; DNA-binding; Reference proteome;
KW Septation.
FT CHAIN 1..283
FT /note="Nucleoid occlusion protein"
FT /id="PRO_0000346624"
FT DNA_BIND 148..167
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ SEQUENCE 283 AA; 32782 MW; 8A693DBAF1E31DA8 CRC64;
MKHSFSRLFG LGDKEEEAEI AEHDTNKEEI QEIPVGDIIP NRFQPRTIFS EEKIKELAAT
IHTHGIIQPI VVRKTEREGQ YELIAGERRW RAVQTLDWEK VPAIIKDFSD TETASVALIE
NLQREELSSI EEAHAYARLL ELHDLTQEAL AQRLGKGQST IANKLRLLKL PEEVQEAILK
KEISERHARA LIPLKQPDLQ VKLLHEVIEK SLNVKQTEDR VVKMLEQDKR KPKPKRKAYS
RDARIAMNTI RQSLSMVEDS GVKLNTEEEE FEEYIQFTIR IPK
