NOC_DROME
ID NOC_DROME Reviewed; 537 AA.
AC Q24423;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Zinc finger protein Noc;
DE AltName: Full=Zinc finger protein NocA;
GN Name=noc; Synonyms=nocA; ORFNames=CG4491;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=8289824; DOI=10.1128/mcb.14.2.1487-1499.1994;
RA Cheah P.Y., Meng Y.B., Yang X., Kimbrell D., Ashburner M., Chia W.;
RT "The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger protein
RT involved in the development of the embryonic brain and the adult ocellar
RT structures.";
RL Mol. Cell. Biol. 14:1487-1499(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, INTERACTION WITH ELB, AND DEVELOPMENTAL STAGE.
RX PubMed=12117809; DOI=10.1242/dev.129.15.3585;
RA Dorfman R., Glazer L., Weihe U., Wernet M.F., Shilo B.-Z.;
RT "Elbow and Noc define a family of zinc finger proteins controlling
RT morphogenesis of specific tracheal branches.";
RL Development 129:3585-3596(2002).
RN [6]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=14757638; DOI=10.1242/dev.00979;
RA Weihe U., Dorfman R., Wernet M.F., Cohen S.M., Milan M.;
RT "Proximodistal subdivision of Drosophila legs and wings: the elbow-no
RT ocelli gene complex.";
RL Development 131:767-774(2004).
RN [7]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=17014842; DOI=10.1016/j.ydbio.2006.07.050;
RA Luque C.M., Milan M.;
RT "Growth control in the proliferative region of the Drosophila eye-head
RT primordium: the elbow-noc gene complex.";
RL Dev. Biol. 301:327-339(2007).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-157 AND SER-208, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May negatively regulate Notch-induced cell proliferation in
CC the eye-head primordium. Required for development of the
CC supraesophageal ganglion and ocelli. May act in leg and wing primordia
CC to negatively regulate body-wall specifying genes and thereby promote
CC appendage formation. Plays a role in tracheal development.
CC {ECO:0000269|PubMed:12117809, ECO:0000269|PubMed:14757638,
CC ECO:0000269|PubMed:17014842, ECO:0000269|PubMed:8289824}.
CC -!- SUBUNIT: Interacts with elB. {ECO:0000269|PubMed:12117809}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the adult head.
CC {ECO:0000269|PubMed:8289824}.
CC -!- DEVELOPMENTAL STAGE: Expressed from stage 4 in the embryonic termini
CC and at stage 5/6 in the ectodermal stripes. Expressed in the
CC invaginating tracheal pits at stage 11, and ubiquitously throughout the
CC embryo from stage 13. Expressed in the highly proliferative region of
CC the eye-head primordium. Expressed in the distal regions of leg and
CC wing imaginal discs. Expressed predominantly in embryo and pupae.
CC {ECO:0000269|PubMed:12117809, ECO:0000269|PubMed:14757638,
CC ECO:0000269|PubMed:17014842, ECO:0000269|PubMed:8289824}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR EMBL; L14009; AAA16473.1; -; mRNA.
DR EMBL; AE014134; AAF53399.1; -; Genomic_DNA.
DR EMBL; AY070550; AAL48021.1; -; mRNA.
DR PIR; A55929; A55929.
DR RefSeq; NP_001285932.1; NM_001299003.1.
DR RefSeq; NP_476917.1; NM_057569.3.
DR AlphaFoldDB; Q24423; -.
DR BioGRID; 60871; 21.
DR DIP; DIP-19280N; -.
DR IntAct; Q24423; 4.
DR STRING; 7227.FBpp0080215; -.
DR iPTMnet; Q24423; -.
DR PaxDb; Q24423; -.
DR DNASU; 34847; -.
DR EnsemblMetazoa; FBtr0080643; FBpp0080215; FBgn0005771.
DR EnsemblMetazoa; FBtr0342913; FBpp0309705; FBgn0005771.
DR GeneID; 34847; -.
DR KEGG; dme:Dmel_CG4491; -.
DR CTD; 34847; -.
DR FlyBase; FBgn0005771; noc.
DR VEuPathDB; VectorBase:FBgn0005771; -.
DR eggNOG; ENOG502QUYV; Eukaryota.
DR HOGENOM; CLU_035082_0_0_1; -.
DR InParanoid; Q24423; -.
DR OMA; CKDPYCQ; -.
DR OrthoDB; 1163882at2759; -.
DR PhylomeDB; Q24423; -.
DR SignaLink; Q24423; -.
DR BioGRID-ORCS; 34847; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34847; -.
DR PRO; PR:Q24423; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0005771; Expressed in wing disc and 79 other tissues.
DR ExpressionAtlas; Q24423; baseline and differential.
DR Genevisible; Q24423; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR GO; GO:0001752; P:compound eye photoreceptor fate commitment; IGI:FlyBase.
DR GO; GO:0035214; P:eye-antennal disc development; IGI:FlyBase.
DR GO; GO:0035218; P:leg disc development; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:FlyBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0008056; P:ocellus development; IMP:UniProtKB.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0007430; P:terminal branching, open tracheal system; IMP:UniProtKB.
DR GO; GO:0035220; P:wing disc development; IMP:UniProtKB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Metal-binding; Notch signaling pathway;
KW Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..537
FT /note="Zinc finger protein Noc"
FT /id="PRO_0000292212"
FT ZN_FING 402..430
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 64..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 157
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 537 AA; 53996 MW; D5913F8D502148CB CRC64;
MVVLEGGGGV VTIGNNQYLQ PDYLAPLPTT MDAKKSPLAL LAQTCSQIGA DSSAVKPLLA
MDKNKTKPGA CSSSSNSSSS SGSAEISAAK SPSGQAKSPK SSTPISSTAT SASLSNTSTG
EIKLAFKPYE TNVLSHQNQN SFKSSSSLDA EPTRPSSKNS SSAQERVPSR SKSNATPTDG
GKAEISAHDS SSSRKTVSPS GSSQRGASPI VRSGMEVLNN ANGTAQHPKE MSSMAAAAAA
AAAAYKAAGP YGLNPLSALC CPPGMEQHAN PAFRPPFAGG FSHHHAAMLA VAANGGYPGG
APGGGPAGQP NPYISYQRIK TPAGGEAIVP VCKDPYCQGC PYSAHTQQML MGAPCPAGCT
QCEHQKYGLA MASAAGLPPA HPYSQAAAAA AANAAAARSA PYVCSWVVGD AYCGKRFQTS
DELFSHLRTH TGNLSDPAAA AAALAQSQAQ SLLGTLFPPS ALRAGYPTPP LSPMSAAAAA
ARYHPYAKPP PGALAGGPSP FGAAGAFNPA AAAAAAALGP YYSPYAMYGQ RMGAAHQ
