ID   NOC_GEOSW               Reviewed;         281 AA.
AC   C5D9Y4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE            Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   Name=noc {ECO:0000255|HAMAP-Rule:MF_02015}; OrderedLocusNames=GWCH70_3426;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC       nonspecifically to DNA and preventing the assembly of the division
CC       machinery in the vicinity of the nucleoid, especially under conditions
CC       that disturb the cell cycle. It helps to coordinate cell division and
CC       chromosome segregation by preventing the formation of the Z ring
CC       through the nucleoid, which would cause chromosome breakage.
CC       {ECO:0000255|HAMAP-Rule:MF_02015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
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DR   EMBL; CP001638; ACS26062.1; -; Genomic_DNA.
DR   RefSeq; WP_015865420.1; NC_012793.1.
DR   AlphaFoldDB; C5D9Y4; -.
DR   SMR; C5D9Y4; -.
DR   STRING; 471223.GWCH70_3426; -.
DR   EnsemblBacteria; ACS26062; ACS26062; GWCH70_3426.
DR   KEGG; gwc:GWCH70_3426; -.
DR   eggNOG; COG1475; Bacteria.
DR   HOGENOM; CLU_023853_0_1_9; -.
DR   OMA; SQSYVAN; -.
DR   OrthoDB; 653368at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   HAMAP; MF_02015; ParB_Noc; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR023705; Nucleoid_occlusion_protein.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Septation.
FT   CHAIN           1..281
FT                   /note="Nucleoid occlusion protein"
FT                   /id="PRO_1000216415"
FT   DNA_BIND        145..164
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ   SEQUENCE   281 AA;  32620 MW;  AC96D35CA2B71269 CRC64;
     MKHPFSRFFS FGEKEQEETM EKQEKEEVRK IPVSKIVPNR FQPRTIFDEE KIEELALTIH
     THGIIQPIVV RECEDGKFEI IAGERRWRAV QKLGWSEIPA IIKNLNDKET ASVALIENLQ
     REELTPIEEA MAYAKLLELH NLTQEALAQR LGKGQSTIAN KLRLLKLPQE VQEALLHRTI
     TERHARALIV LKDKEKQLKL LQEIIDKQLN VKQTEDRVLK MLEAANPKPK PKRKAFSKDM
     RIAVNTIRQS LTMVANSGVA VDSEEEEFED YYQITIRIPK K