ID   NOC_GEOTN               Reviewed;         281 AA.
AC   A4ITW8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE            Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   Name=noc {ECO:0000255|HAMAP-Rule:MF_02015}; OrderedLocusNames=GTNG_3437;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC       nonspecifically to DNA and preventing the assembly of the division
CC       machinery in the vicinity of the nucleoid, especially under conditions
CC       that disturb the cell cycle. It helps to coordinate cell division and
CC       chromosome segregation by preventing the formation of the Z ring
CC       through the nucleoid, which would cause chromosome breakage.
CC       {ECO:0000255|HAMAP-Rule:MF_02015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
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DR   EMBL; CP000557; ABO68772.1; -; Genomic_DNA.
DR   RefSeq; WP_008880825.1; NC_009328.1.
DR   AlphaFoldDB; A4ITW8; -.
DR   SMR; A4ITW8; -.
DR   STRING; 420246.GTNG_3437; -.
DR   EnsemblBacteria; ABO68772; ABO68772; GTNG_3437.
DR   KEGG; gtn:GTNG_3437; -.
DR   eggNOG; COG1475; Bacteria.
DR   HOGENOM; CLU_023853_0_1_9; -.
DR   OMA; SQSYVAN; -.
DR   OrthoDB; 653368at2; -.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   HAMAP; MF_02015; ParB_Noc; 1.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR023705; Nucleoid_occlusion_protein.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Septation.
FT   CHAIN           1..281
FT                   /note="Nucleoid occlusion protein"
FT                   /id="PRO_0000346630"
FT   DNA_BIND        145..164
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  32418 MW;  8930F31B863B53FA CRC64;
     MKHPFSRLFS FGEKEQEEAG GKQEREEVRN IPVASIIPNR FQPRTVFDEE KIAELALTIR
     THGIIQPIVV RECDNGQFEI IAGERRWRAV QKLGWTEIPA IIKNLNDKET ASVALIENLQ
     REELTPIEEA MAYARLIELH DLTQEALAQR LGKGQSTIAN KLRLLKLPQE VQEALLQRAI
     TERHARALIA LKDKEKQLKL LQEIIDKQLN VKQTEDRVLK MLEAGERKPK PKRKAFSRDM
     RIAVNTIRQS LSMVENSGVS VHSEEEEFDD YYQITIRIAK K