ID   NOC_LYSSC               Reviewed;         298 AA.
AC   B1HPM0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE            Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   Name=noc {ECO:0000255|HAMAP-Rule:MF_02015}; OrderedLocusNames=Bsph_4778;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC       nonspecifically to DNA and preventing the assembly of the division
CC       machinery in the vicinity of the nucleoid, especially under conditions
CC       that disturb the cell cycle. It helps to coordinate cell division and
CC       chromosome segregation by preventing the formation of the Z ring
CC       through the nucleoid, which would cause chromosome breakage.
CC       {ECO:0000255|HAMAP-Rule:MF_02015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
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DR   EMBL; CP000817; ACA42222.1; -; Genomic_DNA.
DR   RefSeq; WP_012296220.1; NC_010382.1.
DR   AlphaFoldDB; B1HPM0; -.
DR   SMR; B1HPM0; -.
DR   EnsemblBacteria; ACA42222; ACA42222; Bsph_4778.
DR   KEGG; lsp:Bsph_4778; -.
DR   HOGENOM; CLU_023853_0_1_9; -.
DR   OMA; SQSYVAN; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   HAMAP; MF_02015; ParB_Noc; 1.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR023705; Nucleoid_occlusion_protein.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Septation.
FT   CHAIN           1..298
FT                   /note="Nucleoid occlusion protein"
FT                   /id="PRO_0000346635"
FT   DNA_BIND        152..171
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ   SEQUENCE   298 AA;  34201 MW;  3239EE3A0D39A34F CRC64;
     MKSPFSRFFG GGSKTEPIVK NEVEQAEAVH TAEEVIKLPI DQIVPNRFQP RTIFDDEKIE
     ELSRTIHTHG VIQPIVVRKT SENQYEIIAG ERRYRAMKKL QWTEVPAIVR NLTDKETASI
     ALIENLQREE LTAIEEAVAY QKLLELHELT QEALAQRLGK GQSTVANKLR LLRLPDEVQQ
     AILQRKISER HARALIAIKD QPLQLEVLQQ TVDNDWNVRQ LEEQIQAILH PVTDEQESVP
     KKAKPKRKAI SKDVRIALNT IKQSLTMVTK SGITVKTEEE DTEEYYQITV KIPKKKKV