ID   NOC_OCEIH               Reviewed;         286 AA.
AC   Q8EKU5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015};
DE            Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015};
GN   Name=noc {ECO:0000255|HAMAP-Rule:MF_02015}; OrderedLocusNames=OB3488;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC       nonspecifically to DNA and preventing the assembly of the division
CC       machinery in the vicinity of the nucleoid, especially under conditions
CC       that disturb the cell cycle. It helps to coordinate cell division and
CC       chromosome segregation by preventing the formation of the Z ring
CC       through the nucleoid, which would cause chromosome breakage.
CC       {ECO:0000255|HAMAP-Rule:MF_02015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02015}.
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DR   EMBL; BA000028; BAC15444.1; -; Genomic_DNA.
DR   RefSeq; WP_011067886.1; NC_004193.1.
DR   AlphaFoldDB; Q8EKU5; -.
DR   SMR; Q8EKU5; -.
DR   STRING; 221109.22779178; -.
DR   EnsemblBacteria; BAC15444; BAC15444; BAC15444.
DR   KEGG; oih:OB3488; -.
DR   eggNOG; COG1475; Bacteria.
DR   HOGENOM; CLU_023853_0_1_9; -.
DR   OMA; SQSYVAN; -.
DR   OrthoDB; 653368at2; -.
DR   PhylomeDB; Q8EKU5; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   HAMAP; MF_02015; ParB_Noc; 1.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR023705; Nucleoid_occlusion_protein.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR04285; nucleoid_noc; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Reference proteome;
KW   Septation.
FT   CHAIN           1..286
FT                   /note="Nucleoid occlusion protein"
FT                   /id="PRO_0000346636"
FT   DNA_BIND        147..166
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02015"
SQ   SEQUENCE   286 AA;  33116 MW;  313E5F9EB56D9BA4 CRC64;
     MVHPFNRIFG KSDKENIDTD EVEYSTDEVI QIKVDNIHPN RYQPRTIFQE EKIKELAQTI
     HTHGMIQPIV VRKLEDEDTY ELIAGERRWR AVQHLGWEQV SAIIRDMTDT ETASVALIEN
     LQREELTVIE EAIAYSKLLE LHSLTQEALA QRLGKNQSTV ANKLRLLKLP EEVQTALLDK
     AISERHARAL IKLKQEDQQI AVLHEILEKG LNVKQTEDRI AQINEPKEKK KPKPKFKGVN
     KDIRIAMNTI RQSLNMVSDT GVEVESDEKE LDDYYQITIK IPKKNQ