位置:首页 > 蛋白库 > NOD3C_XENTR
NOD3C_XENTR
ID   NOD3C_XENTR             Reviewed;         401 AA.
AC   Q800B8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Nodal homolog 3-C;
DE   AltName: Full=Nodal-related protein 3-C;
DE   AltName: Full=Xtnr3-C;
DE   Flags: Precursor;
GN   Name=nodal3-C {ECO:0000250|UniProtKB:Q91620};
GN   Synonyms=nr3-C {ECO:0000312|EMBL:BAC75532.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAC75532.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BMP4, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:14697360};
RX   PubMed=14697360; DOI=10.1016/j.ydbio.2003.09.015;
RA   Haramoto Y., Tanegashima K., Onuma Y., Takahashi S., Sekizaki H.,
RA   Asashima M.;
RT   "Xenopus tropicalis nodal-related gene 3 regulates BMP signaling: an
RT   essential role for the pro-region.";
RL   Dev. Biol. 265:155-168(2004).
CC   -!- FUNCTION: Exhibits mesoderm-dorsalizing activity and neural-inducing
CC       activity, but lacks mesoderm-inducing activity. Regulates the
CC       expression of specific mesodermal and neural genes. Induces convergent
CC       extension movements at the embryonic midline by activating the fgf
CC       signaling pathway to induce t/bra expression in the organizer region.
CC       Acts with wnt11 to induce Spemann organizer cells and induce axis
CC       formation (By similarity). The unprocessed protein antagonizes bmp-
CC       signaling. {ECO:0000250|UniProtKB:Q91609, ECO:0000269|PubMed:14697360}.
CC   -!- SUBUNIT: Monomer (By similarity). The propeptide region interacts with
CC       bmp4 in a non-covalent manner. {ECO:0000250,
CC       ECO:0000269|PubMed:14697360}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q91620}.
CC   -!- TISSUE SPECIFICITY: Expressed in the dorsal marginal region of late
CC       blastula, becoming restricted to the Spemann organizer at the early
CC       gastrula stage. {ECO:0000269|PubMed:14697360}.
CC   -!- DEVELOPMENTAL STAGE: First detected at the blastula stage (stage 8).
CC       Expression peaks through the mid-blastula (stage 8.5) to early gastrula
CC       (stage 10) and then decreases during gastrulation.
CC       {ECO:0000269|PubMed:14697360}.
CC   -!- DOMAIN: The propeptide region is both necessary and sufficient for bmp-
CC       inhibitory activity. The propeptide region and the N- and C-terminal
CC       thirds of the mature protein are necessary for neural induction
CC       activity. Although cleavage doesn't appear essential for activity,
CC       residues surrounding the cleavage site are necessary for activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB093329; BAC75532.1; -; mRNA.
DR   RefSeq; NP_001106377.1; NM_001112906.1.
DR   AlphaFoldDB; Q800B8; -.
DR   STRING; 8364.ENSXETP00000019730; -.
DR   GeneID; 100127175; -.
DR   CTD; 100127175; -.
DR   InParanoid; Q800B8; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0070698; F:type I activin receptor binding; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Developmental protein; Disulfide bond;
KW   Gastrulation; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..274
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000338458"
FT   CHAIN           275..401
FT                   /note="Nodal homolog 3-C"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000338459"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        299..365
FT                   /evidence="ECO:0000250|UniProtKB:P43021"
FT   DISULFID        328..396
FT                   /evidence="ECO:0000250|UniProtKB:P43021"
SQ   SEQUENCE   401 AA;  45788 MW;  ECF55E5BE2B99F6F CRC64;
     MAFLSLFLCL VFSSPLMAMP PALQGRKAIS PASILKGPST DNGARDFHGR KFPHFMMQLY
     QNIISRRDKD LSNLEHPTLQ ESDTVQSFIA KSYTTKGNHW TLFFDMSSIS TSNELKSAEL
     RICLPSFGKS HSVTVEIYHT KDDKEKLFMG SFKTKISSAL DADCKVFNLT MVLHNYLTKG
     KRLIKDEYIQ AKGLLLRDLE KSATETGAER VDIVKQDKHH VSDFSAERII LVVFAKEKDH
     AKPDPPSLGK KLFPSKYGMA DSANKVNGFR RLRRNKKEKT RMDVGTTPPK PVEEIKPKCR
     KVDMFVDFQK IGWGSWIVYP KAYNAYRCES ACAVPLNETD DATNYSYIKS LLPLSDTDRR
     ECPSCVPVKM RSMSMLYYEN EDFVLRHHEE MIVEECGYKD I
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024