ID   NODD1_NEOGA             Reviewed;         310 AA.
AC   P50331;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Nodulation protein D 1;
GN   Name=nodD1;
OS   Neorhizobium galegae (Rhizobium galegae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Neorhizobium.
OX   NCBI_TaxID=399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HAMBI 1174;
RX   PubMed=10474187; DOI=10.1111/j.1574-6968.1999.tb13735.x;
RA   Suominen L., Paulin L., Saano A., Saren A.-M., Tas E., Lindstroem K.;
RT   "Identification of nodulation promoter (nod-box) regions of Rhizobium
RT   galegae.";
RL   FEMS Microbiol. Lett. 177:217-223(1999).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X87578; CAA60880.1; -; Genomic_DNA.
DR   RefSeq; WP_041365343.1; NZ_VZUL01000003.1.
DR   AlphaFoldDB; P50331; -.
DR   SMR; P50331; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Nodulation protein D 1"
FT                   /id="PRO_0000105709"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   310 AA;  35517 MW;  93C77DBACD992260 CRC64;
     MRFRGLDLNL LVALDALMTE RQLTAAARRI NLSQPAMSAA IARLRNYFHD DLFVMQGREL
     ILTPRAEALA PAVRDTLLHI QLSVIAWDPI KPAESDRRFR IILSDFMTLI FMEKVIKRIA
     REAPRVTFEL LPLDDDPDEL LRRGDVDFLI LPDLLMPNIH PKAKLFDETL VCVGCPMNKQ
     LEDRLSMEKF MSMGHVAAKF GRLMKPSVEQ WLLLEHGFRR RIELVVPGFT LIPPLLVGTD
     RIATLPMRLV KHFEQTIPLK IVEHPLPPLH FPLAVQWPAL HNTDPGNIWM REIMFDEASR
     MEASSETSAV