ID   NODD1_RHILO             Reviewed;         314 AA.
AC   Q52838;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Nodulation protein D 1;
GN   Name=nodD1; Synonyms=nodD; OrderedLocusNames=mll6179;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
RC   STRAIN=NZP 2213;
RX   PubMed=8850088; DOI=10.1094/mpmi-9-0187;
RA   Scott D.B., Young C.A., Collins-Emerson J.M., Terzaghi E.A., Rockman E.S.,
RA   Lewis P.E., Pankhurst C.E.;
RT   "Novel and complex chromosomal arrangement of Rhizobium loti nodulation
RT   genes.";
RL   Mol. Plant Microbe Interact. 9:187-197(1996).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavenoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; BA000012; BAB52513.1; -; Genomic_DNA.
DR   EMBL; L06241; AAB47350.1; -; Genomic_DNA.
DR   RefSeq; WP_010913834.1; NC_002678.2.
DR   AlphaFoldDB; Q52838; -.
DR   SMR; Q52838; -.
DR   STRING; 266835.14025914; -.
DR   EnsemblBacteria; BAB52513; BAB52513; BAB52513.
DR   KEGG; mlo:mll6179; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   OMA; DVDFLIF; -.
DR   OrthoDB; 1591366at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..314
FT                   /note="Nodulation protein D 1"
FT                   /id="PRO_0000105710"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        14..18
FT                   /note="LDALL -> PDWPR (in Ref. 2; AAB47350)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  35692 MW;  54D7D418CE186398 CRC64;
     MRFKGLDLNL LVVLDALLTE RTLTAAASSI NLSQPAMSAA VARLRDYFND ELFTTSGRER
     VLTPRAETLA PAVRSALLQI QCSIISWDPF NPAQSDRRFR IILSDFATLV FFEKVVERVA
     REAPAVSFEL LPIDDDPDEL LRRGDVDFLI FPELFMSSAH PRAALFDETL VCVGCSTNKQ
     LPRQLTFERY MSMRHVAVKF GRTLKPSIEE QFFLEHGLKR RVEIVVQAFS MIPPMVSGTA
     RIATMPFRLV QHFKKTFPLR IIELPLPLPT FTEAVQWPAL HNSDPASIWL REILLQEASR
     MTSPGDAKRR PRQP