ID   NODD1_RHILP             Reviewed;         314 AA.
AC   P23718;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Nodulation protein D 1;
GN   Name=nodD1;
OS   Rhizobium leguminosarum bv. phaseoli.
OG   Plasmid sym.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8002;
RX   PubMed=2215216; DOI=10.1111/j.1365-2958.1990.tb00665.x;
RA   Davis E.O., Johnston A.W.B.;
RT   "Analysis of three nodD genes in Rhizobium leguminosarum biovar phaseoli;
RT   nodD1 is preceded by noIE, a gene whose product is secreted from the
RT   cytoplasm.";
RL   Mol. Microbiol. 4:921-932(1990).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X54214; CAA38126.1; -; Genomic_DNA.
DR   PIR; S11787; S11787.
DR   RefSeq; WP_018247214.1; NZ_WNKD01000037.1.
DR   AlphaFoldDB; P23718; -.
DR   SMR; P23718; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..314
FT                   /note="Nodulation protein D 1"
FT                   /id="PRO_0000105712"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   314 AA;  35477 MW;  A17DBC9965DE32B6 CRC64;
     MRFKGLDLNL LVALDALMTE RNLTAAARSI NLSQPAMSAA VGRLRTYFND DLFTMVGREL
     VPTPRAERLA PSVREALLHI QVSIISWDPF CPAQSDRCFR VILSDYAALV FFEKVVTRVA
     REAPAVSFEL LPIADNYDEY LRRGDADFLI FPELLMSRAH PKVALFEETL VCVGCHSNKL
     LSEQLTLERY MSMGHVVVKF GNARTASFEE WCLLGHGLKR HVEVVVQGFS MVPFMLSGTE
     RIATMPLRLV KQLEKTIPLR IADLPLPLPA FTQALQWPAL HNSGQASLWM RDVLCQEASR
     MPSPHEVMRR LRIS