ID   NODD1_SINFN             Reviewed;         322 AA.
AC   P55359;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Nodulation protein D 1;
GN   Name=nodD1; OrderedLocusNames=NGR_a00360; ORFNames=y4aL;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Regulates the expression of the nod abcFE genes which encode
CC       other nodulation proteins. NodD is also a negative regulator of its own
CC       expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U00090; AAB91609.1; -; Genomic_DNA.
DR   RefSeq; NP_443771.1; NC_000914.2.
DR   RefSeq; WP_010875078.1; NC_000914.2.
DR   AlphaFoldDB; P55359; -.
DR   SMR; P55359; -.
DR   STRING; 394.NGR_a00360; -.
DR   EnsemblBacteria; AAB91609; AAB91609; NGR_a00360.
DR   KEGG; rhi:NGR_a00360; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   OMA; DVDFLIF; -.
DR   OrthoDB; 1591366at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Nodulation protein D 1"
FT                   /id="PRO_0000105721"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   322 AA;  36460 MW;  07D3BFA31983C233 CRC64;
     MRFKGLDLNL LVALDALMTE RKLTAAARSI NLSQPAMSAA ITRLRTYFRD ELFTMNGREL
     VPTPRAEALA PAVREALLHI HLSIISWDPF NPAQSDRSFR IILSDFMTLM FLERVVVRVA
     REAPAVSFEL LPFSDEPDEL LRRGDVDFLI LPEMFMSHTH PRAKLFDERF VCVSCPTNQK
     LPPQLSIDNY VSMGHVAAQF GKQRPSVEEW LLREHGLRRR VEVAVPGFTM IPSFLSGTDR
     IATLPLRLAM HFAKAIPLRI TELPQPIFPA FTEAVQWPAP HSSDPASLWM REIFLQEASR
     VEFQSETSAH ALSKADGAIR HP