ID   NODD2_BRADU             Reviewed;         330 AA.
AC   Q45263;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Nodulation protein D 2;
GN   Name=nodD2; OrderedLocusNames=bll2021;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=1421512; DOI=10.1094/mpmi-5-257;
RA   Goettfert M., Holzhauser D., Bani D., Hennecke H.;
RT   "Structural and functional analysis of two different nodD genes in
RT   Bradyrhizobium japonicum USDA110.";
RL   Mol. Plant Microbe Interact. 5:257-265(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 110spc4;
RX   PubMed=11157954; DOI=10.1128/jb.183.4.1405-1412.2001;
RA   Goettfert M., Roethlisberger S., Kuendig C., Beck C., Marty R.,
RA   Hennecke H.;
RT   "Potential symbiosis-specific genes uncovered by sequencing a 410-kb DNA
RT   region of the Bradyrhizobium japonicum chromosome.";
RL   J. Bacteriol. 183:1405-1412(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M81825; AAA26233.1; -; Genomic_DNA.
DR   EMBL; AF322013; AAG60992.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC47286.1; -; Genomic_DNA.
DR   RefSeq; NP_768661.1; NC_004463.1.
DR   RefSeq; WP_011084818.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q45263; -.
DR   SMR; Q45263; -.
DR   STRING; 224911.27350275; -.
DR   PRIDE; Q45263; -.
DR   EnsemblBacteria; BAC47286; BAC47286; BAC47286.
DR   GeneID; 64067254; -.
DR   KEGG; bja:bll2021; -.
DR   PATRIC; fig|224911.44.peg.1523; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   InParanoid; Q45263; -.
DR   OMA; CLFRRGH; -.
DR   PhylomeDB; Q45263; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..330
FT                   /note="Nodulation protein D 2"
FT                   /id="PRO_0000105705"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   REGION          308..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  37249 MW;  BE2AAA379EA860A4 CRC64;
     MRFKGLDLNL LVALDALITE RNLSSAARKI NLSQPAMSAA VARLRKHFRD ELFGMRGREL
     VLSSRAEGLA APVREALMHI ELSIMARHPF DPARLNRRFR IVLSDFVTVV LFRNVVARVT
     REAPAVSFEL AAPTDEHELL LRRGEVDFVI RPDFFMSSTH PRAALFEERL VCVGCCTNRE
     LQPRLTFDRY MSMGHVAVKH GGAPRTPVEH SFLTDLGPTR RIDILVQSFS MIPPLIVGTN
     RIGTMPLGLV RHFQRTMPLR IVELPHPFPA FTEAVQWPSL HNSDPGSLWM RDILFQEATR
     MATTQELRVT SSPEDAEPPG HFVRSVSPLP