ID   NODD2_BRAJP             Reviewed;         312 AA.
AC   P12233; Q45260;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Nodulation protein D 2;
GN   Name=nodD2;
OS   Bradyrhizobium japonicum.
OG   Plasmid sym.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 191;
RX   PubMed=2826389; DOI=10.1128/jb.170.1.12-20.1988;
RA   Appelbaum E.R., Thompson D.V., Idler K., Chartrain N.;
RT   "Rhizobium japonicum USDA 191 has two nodD genes that differ in primary
RT   structure and function.";
RL   J. Bacteriol. 170:12-20(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
RC   STRAIN=USDA 110;
RX   PubMed=3584066; DOI=10.1128/jb.169.6.2631-2638.1987;
RA   Nieuwkoop A.J., Banfalvi Z., Deshmane N., Gerhold D., Schell M.G.,
RA   Sirotkin K.M., Stacey G.;
RT   "A locus encoding host range is linked to the common nodulation genes of
RT   Bradyrhizobium japonicum.";
RL   J. Bacteriol. 169:2631-2638(1987).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M18972; AAA26337.1; -; Genomic_DNA.
DR   EMBL; M16488; AAA26223.1; ALT_SEQ; Genomic_DNA.
DR   PIR; B25979; B25979.
DR   AlphaFoldDB; P12233; -.
DR   SMR; P12233; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Nodulation protein D 2"
FT                   /id="PRO_0000105706"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  35235 MW;  5DEC549EF665D0CB CRC64;
     MRFKGLDLNL LVALDALMTK RSVTAAARSI NLSQPAMSAA IARLRTYFGD DLFTMRGREL
     IPTPRAIALA PAVRDALLHI QFSIISWDMF NPVQSQRRFR IRLSDVIMLV FFERVVKRLA
     REAPGIGFEL LPLTEDPDEL LRYGDVDFVI LPELFASSDH PKAKLLDDTL VCVGCPTNKQ
     LKRQLSFENY GSMGHIAAKF GRTLKPSIEN WLLLEHGLKR RIEVVVPGFS LIPPLLSGTD
     RIATMPLRLV EHFAKTTPLR VAELPLALPP FAQAVQWPSL HNRDQASIWM RQVLLQEALH
     MTTPPDSVEY RP