ID   NODD2_RHILP             Reviewed;         318 AA.
AC   P23719;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Nodulation protein D 2;
GN   Name=nodD2;
OS   Rhizobium leguminosarum bv. phaseoli.
OG   Plasmid sym.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8002;
RX   PubMed=2215216; DOI=10.1111/j.1365-2958.1990.tb00665.x;
RA   Davis E.O., Johnston A.W.B.;
RT   "Analysis of three nodD genes in Rhizobium leguminosarum biovar phaseoli;
RT   nodD1 is preceded by noIE, a gene whose product is secreted from the
RT   cytoplasm.";
RL   Mol. Microbiol. 4:921-932(1990).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X54215; CAA38128.1; -; Genomic_DNA.
DR   PIR; S11789; S11789.
DR   RefSeq; WP_004677768.1; NZ_WNKD01000039.1.
DR   AlphaFoldDB; P23719; -.
DR   SMR; P23719; -.
DR   GeneID; 45960660; -.
DR   GeneID; 58692297; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Nodulation protein D 2"
FT                   /id="PRO_0000105713"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   318 AA;  35636 MW;  928CCF89ABF333E7 CRC64;
     MRFKGLDLNL LVALDALTTE RNLTAAARSI NLSQPAMSAA IGRLRDYFRD ELFTMNGREL
     RLTPRAEGLA SAVRETLLQV QCSIISWEPF NPSKSDRCFR IVLSDFMMLI YFNKIIERVA
     REAPAVSFEL LPLDSDPYEM LSRGDVDFLI VPEFFLSGAH PSAKLFTEKF VCVACSTNVD
     LPSALTIEQY VSTGHVAAAF GRFLKPSVEG WFLLENGIQR RVEVVVQGFS LIPPVLRGTN
     RIANLPLRLV EHYESTFPLR IINLPLPLPV FTEAVQWPAL HNADPGSIWF REILVEEASR
     MMSSNAPKIH GLLQQSGS