ID   NODD3_RHILO             Reviewed;         301 AA.
AC   Q52779;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Nodulation protein D 3;
GN   Name=nodD3; OrderedLocusNames=mlr6182;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NZP 2213;
RX   PubMed=8850088; DOI=10.1094/mpmi-9-0187;
RA   Scott D.B., Young C.A., Collins-Emerson J.M., Terzaghi E.A., Rockman E.S.,
RA   Lewis P.E., Pankhurst C.E.;
RT   "Novel and complex chromosomal arrangement of Rhizobium loti nodulation
RT   genes.";
RL   Mol. Plant Microbe Interact. 9:187-197(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U22899; AAB50274.1; -; Genomic_DNA.
DR   EMBL; BA000012; BAB52515.1; -; Genomic_DNA.
DR   PIR; S21410; S21410.
DR   RefSeq; WP_010913836.1; NC_002678.2.
DR   AlphaFoldDB; Q52779; -.
DR   SMR; Q52779; -.
DR   STRING; 266835.14025916; -.
DR   EnsemblBacteria; BAB52515; BAB52515; BAB52515.
DR   KEGG; mlo:mlr6182; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   OMA; CARPHVM; -.
DR   OrthoDB; 1591366at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Nodulation protein D 3"
FT                   /id="PRO_0000105711"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        135
FT                   /note="N -> H (in Ref. 1; AAB50274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        149
FT                   /note="V -> L (in Ref. 1; AAB50274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        180
FT                   /note="Q -> E (in Ref. 1; AAB50274)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  34224 MW;  F1C49282BBE2CE61 CRC64;
     MRFKGLDLNL LVVLDALLTA RNLTAAASSI NLSQPAMSAA VARLRNYFND ELFTMSGRER
     VLTPRAETLA PAVRGALLHI QCSIISWDPF NPAQSDRRFR IILSDFATLV FFEKVVERVA
     REAPAVSFEL RPLDNDPDEL LRRGDVDFVI LPEFFMSSAH PRAALFDETF VCVGCPTNKQ
     LPRQLTFERY VSMKHIAFRV GGAQMPSIEE QFLLEHGLKR RVEIVVQAFS MIPPMVSGTA
     RIATMPFRLV QHFKKTFPLR IIELPRPLPT FTEAVQWPTL HNSDPASIWM RQIMLQEASR
     M