ID   NODD3_RHILP             Reviewed;         302 AA.
AC   P23720;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nodulation protein D 3;
GN   Name=nodD3;
OS   Rhizobium leguminosarum bv. phaseoli.
OG   Plasmid sym.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8002;
RX   PubMed=2215216; DOI=10.1111/j.1365-2958.1990.tb00665.x;
RA   Davis E.O., Johnston A.W.B.;
RT   "Analysis of three nodD genes in Rhizobium leguminosarum biovar phaseoli;
RT   nodD1 is preceded by noIE, a gene whose product is secreted from the
RT   cytoplasm.";
RL   Mol. Microbiol. 4:921-932(1990).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X54215; CAA38129.1; -; Genomic_DNA.
DR   PIR; S11790; S11790.
DR   RefSeq; WP_004677763.1; NZ_WNKD01000039.1.
DR   AlphaFoldDB; P23720; -.
DR   SMR; P23720; -.
DR   GeneID; 45960661; -.
DR   GeneID; 58692298; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Nodulation protein D 3"
FT                   /id="PRO_0000105714"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   302 AA;  34275 MW;  2B066505295AB5CA CRC64;
     MRFKGLDLNL LVALDALMIE RNLTAAARSI NLSQPAMSAA VRRLRSYFRD ELFTMRGREF
     VPTPRAEDLA PAIREALQHI RLNIIPWDKF TPDQSDRHFR VSLCDFVTVV LFQKILERLA
     REAPGISFDL LPLTDNPDEL LRRGDVDFLI SPPLFMSSAH PKIDLFQERL TCVGCSNNKQ
     LEEALTAEEY SSMGHAVVRF GRTQQPTIED CFLQEHGLKR RVEVVVSSFS MIPAALMGTD
     RIATVPLRLV GLFEDTIPLR MTAPPIALPT FTEAVQWPVL HDKDPANIWM RDIMVQEAAR
     LP