ID   NODD_RHILT              Reviewed;         318 AA.
AC   P04680;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Nodulation protein D;
GN   Name=nodD;
OS   Rhizobium leguminosarum bv. trifolii.
OG   Plasmid sym pRtr843e.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ANU 843;
RX   PubMed=3008100; DOI=10.1093/nar/14.7.2891;
RA   Schofield P.R., Watson J.M.;
RT   "DNA sequence of Rhizobium trifolii nodulation genes reveals a reiterated
RT   and potentially regulatory sequence preceding nodABC and nodFE.";
RL   Nucleic Acids Res. 14:2891-2903(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 207-223.
RC   STRAIN=ANU 843;
RA   Schofield P.R., Djordjevic M.A., Rolfe B.G., Shine J., Watson J.M.;
RT   "A molecular linkage map of nitrogenase and nodulation genes in Rhizobium
RT   trifolii.";
RL   Mol. Gen. Genet. 192:459-465(1983).
RN   [3]
RP   FUNCTIONAL REGIONS.
RA   Spaink H.P., Wijffelman C.A., Okker R.J.H., Lugtenberg B.E.J.;
RT   "Localization of functional regions of the Rhizobium nodD product using
RT   hybrid nodD genes.";
RL   Plant Mol. Biol. 12:59-73(1989).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers. {ECO:0000269|Ref.3}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=Ref.2; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X03721; CAA27354.1; -; Genomic_DNA.
DR   PIR; D23766; D23766.
DR   AlphaFoldDB; P04680; -.
DR   SMR; P04680; -.
DR   PRIDE; P04680; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Nodulation protein D"
FT                   /id="PRO_0000105716"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   318 AA;  36099 MW;  2BED1A485B4B6182 CRC64;
     MRFKGLDLNL LVALDALMTE RKLTAAARSI NLSQPAMSAA IGRLRAYFND ELFLMQQRRL
     VPTPRAEALA PAVREALLHI QLSVIAWDPL VPAESDRRFR IVLSDFMTLV FFEKVIKRVA
     REAPGVSFEL LHVNDDPDER LRSGDLDFLI LPDQFMSATH PSAKLFEDKL VCVGCPSNQQ
     LRGKLSLKRF MSMGHVAAMF GRTLKPSIEQ WLLLEHGFKR RVEIVVPGFN SIPMLLQGTN
     RIATLPLLLV RHFEPTIPLQ IVDHPLPPLS FTEALQWPLL HNSDPGNIWM RNIILEEASR
     IETSSERCSQ EPRATQSW