ID   NODD_RHILV              Reviewed;         303 AA.
AC   P04681;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Nodulation protein D;
GN   Name=nodD;
OS   Rhizobium leguminosarum bv. viciae.
OG   Plasmid sym pRL1JI.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=248;
RX   PubMed=16453679; DOI=10.1002/j.1460-2075.1986.tb04262.x;
RA   Shearman C.A., Rossen L., Johnston A.W.B., Downie J.A.;
RT   "The Rhizobium leguminosarum nodulation gene nodF encodes a polypeptide
RT   similar to acyl-carrier protein and is regulated by nodD plus a factor in
RT   pea root exudate.";
RL   EMBO J. 5:647-652(1986).
CC   -!- FUNCTION: NodD regulates the expression of the nodABCFE genes which
CC       encode other nodulation proteins. NodD is also a negative regulator of
CC       its own expression. Binds flavonoids as inducers.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; Y00548; CAA68622.1; -; Genomic_DNA.
DR   PIR; A25095; A25095.
DR   AlphaFoldDB; P04681; -.
DR   SMR; P04681; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08462; PBP2_NodD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037416; NodD_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nodulation; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..303
FT                   /note="Nodulation protein D"
FT                   /id="PRO_0000105717"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   303 AA;  34487 MW;  1649A7B44CA87046 CRC64;
     MRFKGLDLNL LVALDALMTE RKLTAAARSI NLSQPAMSAA ISRLRDYFRD DLFIMQRREL
     VPTPRAEALA PAVREALLHI QLSVIAWDPI NPAESDRRFR IILSDFMALV FFDKIILRLA
     REAPGVSFEL LPLDDDPEEL LRRGDVDFLI LPDLFMSGAH PKARLFEERL VCVGCPTNEQ
     LQGQLSLEQY MSMGHVAAKF GRGLKPSVEQ WLLMQHGLKR RIELVVPGFN LIPPLLSGTN
     RIATIPLRLV KHYERTIPLR IIEHPLPLVS FTEAVQWPAL HNTDPGNIWM REIMIQEALR
     IGI