NOG1_ARATH
ID NOG1_ARATH Reviewed; 671 AA.
AC Q9C6I8;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Nucleolar GTP-binding protein 1;
GN OrderedLocusNames=At1g50920; ORFNames=F8A12.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU01047}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AY096652; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC079284; AAG50935.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32601.1; -; Genomic_DNA.
DR EMBL; AY096652; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; C96546; C96546.
DR RefSeq; NP_175505.1; NM_103972.3.
DR AlphaFoldDB; Q9C6I8; -.
DR SMR; Q9C6I8; -.
DR IntAct; Q9C6I8; 1.
DR STRING; 3702.AT1G50920.1; -.
DR iPTMnet; Q9C6I8; -.
DR PaxDb; Q9C6I8; -.
DR PRIDE; Q9C6I8; -.
DR ProteomicsDB; 248934; -.
DR EnsemblPlants; AT1G50920.1; AT1G50920.1; AT1G50920.
DR GeneID; 841514; -.
DR Gramene; AT1G50920.1; AT1G50920.1; AT1G50920.
DR KEGG; ath:AT1G50920; -.
DR Araport; AT1G50920; -.
DR TAIR; locus:2036451; AT1G50920.
DR eggNOG; KOG1490; Eukaryota.
DR HOGENOM; CLU_011784_4_1_1; -.
DR InParanoid; Q9C6I8; -.
DR OMA; EWKNDVM; -.
DR OrthoDB; 678655at2759; -.
DR PhylomeDB; Q9C6I8; -.
DR PRO; PR:Q9C6I8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6I8; baseline and differential.
DR Genevisible; Q9C6I8; AT.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR024926; NOG1.
DR InterPro; IPR041623; NOG1_N.
DR InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR InterPro; IPR012973; NOG_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF06858; NOG1; 1.
DR Pfam; PF17835; NOG1_N; 1.
DR Pfam; PF08155; NOGCT; 1.
DR PIRSF; PIRSF038919; NOG1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51710; G_OBG; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..671
FT /note="Nucleolar GTP-binding protein 1"
FT /id="PRO_0000195029"
FT DOMAIN 169..350
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT REGION 516..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 175..182
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 221..225
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 289..292
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT CONFLICT 461
FT /note="R -> S (in Ref. 3; AY096652)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 671 AA; 76849 MW; 9F342E26AEA412BE CRC64;
MVQYNFKRIT VVPNGKEFVD IILSRTQRQT PTVVHKGYKI NRLRQFYMRK VKYTQTNFHA
KLSAIIDEFP RLEQIHPFYG DLLHVLYNKD HYKLALGQVN TARNLISKIS KDYVKLLKYG
DSLYRCKCLK VAALGRMCTV LKRITPSLAY LEQIRQHMAR LPSIDPNTRT VLICGYPNVG
KSSFMNKVTR ADVDVQPYAF TTKSLFVGHT DYKYLRYQVI DTPGILDRPF EDRNIIEMCS
ITALAHLRAA VLFFLDISGS CGYTIAQQAA LFHSIKSLFM NKPLVIVCNK TDLMPMENIS
EEDRKLIEEM KSEAMKTAMG ASEEQVLLKM STLTDEGVMS VKNAACERLL DQRVEAKMKS
KKINDHLNRF HVAIPKPRDS IERLPCIPQV VLEAKAKEAA AMEKRKTEKD LEEENGGAGV
YSASLKKNYI LQHDEWKEDI MPEILDGHNV ADFIDPDILQ RLAELEREEG IREAGVEEAD
MEMDIEKLSD EQLKQLSEIR KKKAILIKNH RLKKTVAQNR STVPRKFDKD KKYTTKRMGR
ELSAMGLDPS SAMDRARSKS RGRKRDRSED AGNDAMDVDD EQQSNKKQRV RSKSRAMSIS
RSQSRPPAHE VVPGEGFKDS TQKLSAIKIS NKSHKKRDKN ARRGEADRVI PTLRPKHLFS
GKRGKGKTDR R
