NOG1_CAEEL
ID NOG1_CAEEL Reviewed; 681 AA.
AC O44411; Q8MXI6;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Nucleolar GTP-binding protein 1 {ECO:0000303|PubMed:24552710};
GN Name=nog-1 {ECO:0000303|PubMed:24552710, ECO:0000312|WormBase:T07A9.9};
GN ORFNames=T07A9.9 {ECO:0000312|WormBase:T07A9.9};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLY-225.
RX PubMed=24552710; DOI=10.14348/molcells.2014.2251;
RA Kim Y.I., Bandyopadhyay J., Cho I., Lee J., Park D.H., Cho J.H.;
RT "Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity
RT through insulin/IGF signaling in C. elegans.";
RL Mol. Cells 37:51-57(2014).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit (By
CC similarity). Has a role in regulating longevity, growth and brood size
CC (PubMed:24552710). May regulate fat storage via the insulin/IGF pathway
CC (PubMed:24552710). {ECO:0000250|UniProtKB:Q02892,
CC ECO:0000269|PubMed:24552710}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:24552710}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:24552710}.
CC -!- DEVELOPMENTAL STAGE: Expressed from early embryonic stages through to
CC adulthood. {ECO:0000269|PubMed:24552710}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in an extended
CC lifespan, reduced brood size, slower growth rate and increased fat
CC storage. {ECO:0000269|PubMed:24552710}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU01047}.
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DR EMBL; BX284604; CCD73980.1; -; Genomic_DNA.
DR PIR; T32580; T32580.
DR RefSeq; NP_741288.1; NM_171242.3.
DR AlphaFoldDB; O44411; -.
DR SMR; O44411; -.
DR BioGRID; 42024; 4.
DR IntAct; O44411; 2.
DR STRING; 6239.T07A9.9a.3; -.
DR iPTMnet; O44411; -.
DR EPD; O44411; -.
DR PaxDb; O44411; -.
DR PeptideAtlas; O44411; -.
DR EnsemblMetazoa; T07A9.9.1; T07A9.9.1; WBGene00020297.
DR EnsemblMetazoa; T07A9.9.2; T07A9.9.2; WBGene00020297.
DR EnsemblMetazoa; T07A9.9.3; T07A9.9.3; WBGene00020297.
DR GeneID; 176863; -.
DR KEGG; cel:CELE_T07A9.9; -.
DR UCSC; T07A9.9a.3; c. elegans.
DR CTD; 176863; -.
DR WormBase; T07A9.9; CE17218; WBGene00020297; nog-1.
DR eggNOG; KOG1490; Eukaryota.
DR GeneTree; ENSGT00390000018475; -.
DR InParanoid; O44411; -.
DR OMA; EWKNDVM; -.
DR OrthoDB; 678655at2759; -.
DR PhylomeDB; O44411; -.
DR SignaLink; O44411; -.
DR PRO; PR:O44411; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00020297; Expressed in larva and 4 other tissues.
DR GO; GO:0005730; C:nucleolus; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0010888; P:negative regulation of lipid storage; IMP:WormBase.
DR GO; GO:2000241; P:regulation of reproductive process; IMP:WormBase.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR024926; NOG1.
DR InterPro; IPR041623; NOG1_N.
DR InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR InterPro; IPR012973; NOG_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF06858; NOG1; 1.
DR Pfam; PF17835; NOG1_N; 1.
DR Pfam; PF08155; NOGCT; 1.
DR PIRSF; PIRSF038919; NOG1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51710; G_OBG; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..681
FT /note="Nucleolar GTP-binding protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000195026"
FT DOMAIN 170..341
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 176..183
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 222..226
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 290..293
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT MUTAGEN 225
FT /note="G->A: Results in aggregate formation within
FT nucleoli."
FT /evidence="ECO:0000269|PubMed:24552710"
SQ SEQUENCE 681 AA; 78487 MW; 9C625B5A29212F26 CRC64;
MTSMYNFKRI TCVPNAQELK DVVLSKTQRK TPTVVHRQYS IGRIRAFYAR KIKFLQQTLH
DKLTQIITEF PKMEEIHPFY SDLMNILYDR DHYKIALGQM NTARHLIDGI AREYVRLMKY
ADSLYRCKML KRAALGRMVK LLKRQKSSFE YLEQVRQHLS RLPSIDPATR TLILCGFPNV
GKSSFINNVT RADVEVQPYA FTTKALYVGH LDYRFLRWQV IDTPGILDQP LEDRNTIEMQ
AVTALAHLKA SVLFMMDVSE QCDRSIEEQL HLFESIRPLF ANKPVLIGLN KVDIRHRSDL
PPEKAALLDQ LEKEGIPIIE TSTLTQEGVM GLRDRACDEL LAQRVEAKIQ AKKITNVEDC
VLNRVFVAYP APRDEKVRAP FVPPGLAAKR AQKKLQEAQE LMETDGDEFA AKIPQKPGKI
GKEKIAKGGS QSTDLGDLRD ENTRRLEREI ELEMQDDYIL DLKKHYMLKN PDEKYDIVPE
IWEGHNLADF VDPEIQSKLE NLLREEELLE QAGEYESDLD SDDEETKEKL KLALQIREKE
KLLTLDHAVN KRIAGRIGSR IHGSRKRDRS MSRLENELGE LGVDVDTKKM KNLQGQCAKP
QLGKKMKVGR SRSLSAVRPA PRDELAFPDE EKRAHVDKLR TKAMRGLRRE AKKGEADRHV
YDLKPKHLFC GKRGNGKTDW R
