ID   NOG1_CHATD              Reviewed;         661 AA.
AC   G0S8F1;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Nucleolar GTP-binding protein 1;
GN   Name=NOG1; ORFNames=CTHT_0029660;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250|UniProtKB:Q02892}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q02892}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. NOG subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS21125.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL988041; EGS21125.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006693421.1; XM_006693358.1.
DR   AlphaFoldDB; G0S8F1; -.
DR   SMR; G0S8F1; -.
DR   STRING; 759272.G0S8F1; -.
DR   EnsemblFungi; EGS21125; EGS21125; CTHT_0029660.
DR   GeneID; 18257004; -.
DR   KEGG; cthr:CTHT_0029660; -.
DR   eggNOG; KOG1490; Eukaryota.
DR   HOGENOM; CLU_011784_4_1_1; -.
DR   OrthoDB; 678655at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IEA:EnsemblFungi.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR024926; NOG1.
DR   InterPro; IPR041623; NOG1_N.
DR   InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR   InterPro; IPR012973; NOG_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF06858; NOG1; 1.
DR   Pfam; PF17835; NOG1_N; 1.
DR   Pfam; PF08155; NOGCT; 1.
DR   PIRSF; PIRSF038919; NOG1; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   3: Inferred from homology;
KW   Coiled coil; GTP-binding; Magnesium; Metal-binding; Nucleotide-binding;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..661
FT                   /note="Nucleolar GTP-binding protein 1"
FT                   /id="PRO_0000435807"
FT   DOMAIN          167..339
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   REGION          549..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         173..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         180
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         198..202
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         200
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         219..222
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         287..290
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         320..322
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   661 AA;  75499 MW;  49DD0B0DC372E229 CRC64;
     MTGWKDIPPV PTAQEFIDIV LSRTQRRLPT QIRPGFKISR IRAFYTRKVK FTQETCSEKF
     GAIISSFPVL SDQHPFHRDL MNILYDADHF KVALGQISTA KNLIETISRD YVRLLKYAQS
     LYQCKQLKRA ALGRMATLIK RLKDPLIYLD QVRQHLARLP DINPTTRTLL VAGFPNVGKS
     SFVRSVTRAD TPVEPYAFTT KSLFVGHLDY KYLRYQVIDT PGILDHPLEE MNTIEMQSVT
     ALAHLRAAVL YFMDISEQCG FSLKAQINLF KSIKPLFANK MVFIVLNKMD IKKFEELDPE
     MQQEINDLTK SGEVEILRAS CATQEGVQEV KNHVCERLLV ERVSQKLKAG THSNGNIGTR
     LQEVMARIHV ATPMDGTTRE TFIPEAVKNL KKYDKNDPNR RVLARDIEEA NGGAGVFNVD
     LRKDWILENP EWKYDKIPEI FDGKNVYDYI DPDIDAKLQA LEEEEERLEK EGFYDEDDDL
     PDEEEEEILQ KAEYIREQHA LIRNEAKMRK SLKNRAIIPR KAVKKPLSQL EDHLDQLGVD
     TEAIGLRARA QTAQSSRGRS LVRSRGTTAD PDAMDIDDGA ASAKERLARS RSRARSVAAT
     NRLQDGVQGT TLRSKAERQA KLAQRKMNRM ARQGEADRHI HASMPKHLFS GKRTIGKTDR
     R