NOG1_DICDI
ID NOG1_DICDI Reviewed; 674 AA.
AC Q54N72;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Probable nucleolar GTP-binding protein 1;
GN Name=nog1; ORFNames=DDB_G0285465;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16782229; DOI=10.1016/j.ejcb.2006.05.008;
RA Koch K.V., Reinders Y., Ho T.-H., Sickmann A., Graef R.;
RT "Identification and isolation of Dictyostelium microtubule-associated
RT protein interactors by tandem affinity purification.";
RL Eur. J. Cell Biol. 85:1079-1090(2006).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU01047}.
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DR EMBL; AAFI02000079; EAL64570.1; -; Genomic_DNA.
DR RefSeq; XP_638071.1; XM_632979.1.
DR AlphaFoldDB; Q54N72; -.
DR SMR; Q54N72; -.
DR STRING; 44689.DDB0233587; -.
DR PaxDb; Q54N72; -.
DR PRIDE; Q54N72; -.
DR EnsemblProtists; EAL64570; EAL64570; DDB_G0285465.
DR GeneID; 8625117; -.
DR KEGG; ddi:DDB_G0285465; -.
DR dictyBase; DDB_G0285465; nog1.
DR eggNOG; KOG1490; Eukaryota.
DR HOGENOM; CLU_011784_4_1_1; -.
DR InParanoid; Q54N72; -.
DR OMA; EWKNDVM; -.
DR PhylomeDB; Q54N72; -.
DR PRO; PR:Q54N72; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0005525; F:GTP binding; ISS:dictyBase.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR024926; NOG1.
DR InterPro; IPR041623; NOG1_N.
DR InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR InterPro; IPR012973; NOG_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF06858; NOG1; 1.
DR Pfam; PF17835; NOG1_N; 1.
DR Pfam; PF08155; NOGCT; 1.
DR PIRSF; PIRSF038919; NOG1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51710; G_OBG; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..674
FT /note="Probable nucleolar GTP-binding protein 1"
FT /id="PRO_0000331215"
FT DOMAIN 169..346
FT /note="OBG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT REGION 518..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 175..182
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 221..225
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT BINDING 289..292
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ SEQUENCE 674 AA; 77632 MW; 920A285423EC59BD CRC64;
MVLYNFKKIQ VVPTSKDFID IVLSKTQRKT PTEIHKQYAI GRIRTFYMRK VKYTAQSYHE
KLTQIIGDFP LLDDIHPFYA DLINVLYDKD HYKLALGQLN TARNLIDNLS KDYLRLLKYG
DSLYRCKQLK RASLGRMCTL MLKQGPSLQY LEQVRQHLAR LPSIDPNTRT LLLTGYPNVG
KSSFMNKLTR ANVDVQPYAF TTKSLFVGHT DFKYNTWQVI DTPGILDHPL DERNTIEMQS
ITALAHLHSC VLFLIDISER CGYTIKQQVD LFFSIKALFL NKPLLVVLNK IDARRPEDVP
EDDWKLIQSL ADPARGGIGG THLIPMSNLT EEGIAKVKDT ACSILFEERV EKKLKSTRIE
KEIHRLHLAQ PQARDKKVRA PCIPESVIAA ARQADMDEES DYKKPTLTAA MMEMIEEHEN
DEKYAQGIIP IYDVNAWKKK YLLKNDEWKF DIVPEIINGQ NIADFVDPDI LKRLEELEME
EEAFLEELKN AEDDEESDLD EENEALYDEI QEKKHELRIN HQIKDSSKPQ LSKGRRGIDT
KEMASHLKSM HHEDDEIGDI IQSVRDHSKS RISGKKRSRS ASRSDSQAPT SEERGLSLNR
SKSRQRSTTR IASPAPGEGF HDLAQKEKAD KLDKRSRKKR NQDGRKGESD RHVYNLMPKH
LFSGKRSGGT NDFR
