ID   NOG1_ENCCU              Reviewed;         528 AA.
AC   Q8SVJ8;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Nucleolar GTP-binding protein 1;
GN   Name=NOG1; OrderedLocusNames=ECU05_0800;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU01047}.
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DR   EMBL; AL590445; CAD26599.1; -; Genomic_DNA.
DR   RefSeq; NP_597422.1; NM_001041288.1.
DR   AlphaFoldDB; Q8SVJ8; -.
DR   SMR; Q8SVJ8; -.
DR   STRING; 284813.Q8SVJ8; -.
DR   PRIDE; Q8SVJ8; -.
DR   GeneID; 859087; -.
DR   KEGG; ecu:ECU05_0800; -.
DR   VEuPathDB; MicrosporidiaDB:ECU05_0800; -.
DR   HOGENOM; CLU_011784_5_1_1; -.
DR   InParanoid; Q8SVJ8; -.
DR   OMA; ISAYRCK; -.
DR   OrthoDB; 678655at2759; -.
DR   Proteomes; UP000000819; Chromosome V.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR041623; NOG1_N.
DR   InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR   InterPro; IPR012973; NOG_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF06858; NOG1; 1.
DR   Pfam; PF17835; NOG1_N; 1.
DR   Pfam; PF08155; NOGCT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..528
FT                   /note="Nucleolar GTP-binding protein 1"
FT                   /id="PRO_0000195032"
FT   DOMAIN          168..335
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   REGION          470..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..490
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..519
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         174..181
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         220..224
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         287..290
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   528 AA;  61339 MW;  E84804BA4EA5E9DE CRC64;
     MKANFGYITP VPLNMELIDI SLSKTQKRTP TVIHPQYNIV KIRMFYMRKV KHAGNEFASR
     LGTILTDFPR IEDIHPFYGD LINVLYDRDH YKLALGHVNA AKNGIEKVSK EFVKLLKFAD
     SLYRCKQLKR AALGRMASAA KKLGKTLEYL EEVRMHMSRL PSIDLSGRTL LVCGFPNVGK
     SSFVRKISRA DVEVQPYPFT TKSLYVGHFD YKYLQWQVID TPGILDQPLE NRNTIEMLSI
     TALAHIKAVV LYFIDLSETC GYSVEEQMDL FNTLNPLLSS NMVIVLSKSD VLGLSGMEDK
     KAIMSFLEGK KYMEMSCEKE ENIDAVKAMA CDLLLDERFE RKINSERLSE YINRITIVRP
     KELREKAESF ICSREVTEIE NEQERYLIPE EYRYDIVPEI VDGKNVADFF DPDIEKKLKE
     VEEEEEGLLP MYCKTYDVLS PEERALKEEV VAGIERRRII NRLREKKRLP DSWKHRSRNS
     GGDIAVHVRR DSKTQVAQPP RLPSKKKARF DDKHYYDRKP KHLYRGRK