ID   NOG1_SCHPO              Reviewed;         642 AA.
AC   O94659; O94333;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Probable nucleolar GTP-binding protein 1;
GN   Name=nog1; ORFNames=SPBC651.01c, SPBC725.18c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-468 AND SER-471, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU01047}.
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DR   EMBL; CU329671; CAA22190.1; -; Genomic_DNA.
DR   PIR; T40600; T40600.
DR   RefSeq; XP_001713127.1; XM_001713075.2.
DR   AlphaFoldDB; O94659; -.
DR   SMR; O94659; -.
DR   BioGRID; 277641; 13.
DR   STRING; 4896.SPBC651.01c.1; -.
DR   iPTMnet; O94659; -.
DR   MaxQB; O94659; -.
DR   PaxDb; O94659; -.
DR   PRIDE; O94659; -.
DR   EnsemblFungi; SPBC651.01c.1; SPBC651.01c.1:pep; SPBC651.01c.
DR   PomBase; SPBC651.01c; nog1.
DR   VEuPathDB; FungiDB:SPBC651.01c; -.
DR   eggNOG; KOG1490; Eukaryota.
DR   HOGENOM; CLU_011784_4_1_1; -.
DR   InParanoid; O94659; -.
DR   OMA; EWKNDVM; -.
DR   PhylomeDB; O94659; -.
DR   PRO; PR:O94659; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005525; F:GTP binding; ISM:PomBase.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; ISO:PomBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR024926; NOG1.
DR   InterPro; IPR041623; NOG1_N.
DR   InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR   InterPro; IPR012973; NOG_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF06858; NOG1; 1.
DR   Pfam; PF17835; NOG1_N; 1.
DR   Pfam; PF08155; NOGCT; 1.
DR   PIRSF; PIRSF038919; NOG1; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   1: Evidence at protein level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..642
FT                   /note="Probable nucleolar GTP-binding protein 1"
FT                   /id="PRO_0000195034"
FT   DOMAIN          169..341
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   REGION          571..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..625
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         175..182
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         221..225
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         289..292
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   MOD_RES         468
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         471
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   642 AA;  72799 MW;  540EDDB1CC523180 CRC64;
     MATAVFKNIT PIPDVNTFLD VVLSRTQRKT PTVIRSGFKI SRIRGFYGRK VKFTQDTITE
     KLDSILQEFP KLNDIHPFHA DLLNILYDRD HLKIALSQLS TAKHLVENVA RDYIRLLKYG
     DSLYRCKQLK RAALGRMATI IKRQKSSLEF LEQVRQHLSR LPAIDPNTRT LLVCGYPNVG
     KSSFMNKVTR AQVDVQPYAF TTKSLFVGHF DYKYLRWQVI DTPGILDHPL EQMNTIEMQS
     ITAMAHLRSA VLYFMDLSEM CGYSVAAQVK LYHSIKPLFA NKVTILVLNK IDAMRPEDLD
     QKNQELLQTI IDDGNVKVVQ TSCVQDIGVM DVRTTACEAL LAARVEQKLK GSRVNNVLNR
     IHLAEPAARD EVARPACIPD SVKTRRAYDA NDPNRRILAR DIEAANGGAG VYNVELRDKY
     ILQDPSWKYD RMPELLDGKN VADFVDPEIE AKLLALDEEE ERLEREGYYD SDQEIEDADE
     EEVLEKASRI REKNKLTMLA ARQKKIKNRP VLPRTAGIRT LDELQSSLQS AGLPSDSIEE
     RARSRARTAA ANEMADGSGV DLLMNEGEEI RSKSIAPRSQ SNRRESGVHA EGARSYADRL
     ARVKQIHRNR MARASESDRH VIAAKPKHLL SGKRGNGKTQ RR