ID   NOG1_TRYBB              Reviewed;         655 AA.
AC   Q9U6A9;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Nucleolar GTP-binding protein 1;
GN   Name=NOG1;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   STRAIN=ISTar1;
RX   PubMed=11112701; DOI=10.1242/jcs.114.1.173;
RA   Park J.-H., Jensen B.C., Kifer C.T., Parsons M.;
RT   "A novel nucleolar G-protein conserved in eukaryotes.";
RL   J. Cell Sci. 114:173-185(2001).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NOPP44/46.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. NOG subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU01047}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF189284; AAF01061.1; -; mRNA.
DR   AlphaFoldDB; Q9U6A9; -.
DR   SMR; Q9U6A9; -.
DR   PRIDE; Q9U6A9; -.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; ISA:GeneDB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR024926; NOG1.
DR   InterPro; IPR041623; NOG1_N.
DR   InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR   InterPro; IPR012973; NOG_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF06858; NOG1; 1.
DR   Pfam; PF17835; NOG1_N; 1.
DR   Pfam; PF08155; NOGCT; 1.
DR   PIRSF; PIRSF038919; NOG1; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   1: Evidence at protein level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Ribosome biogenesis.
FT   CHAIN           1..655
FT                   /note="Nucleolar GTP-binding protein 1"
FT                   /id="PRO_0000195028"
FT   DOMAIN          170..342
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   REGION          389..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..556
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         176..183
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         222..226
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         290..293
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   655 AA;  74797 MW;  3244326657BDA3E6 CRC64;
     MSTIYNFKTV TVVPSYKDFI DIVLSKTQRK TPTVVHKGYH ISRIRQFYMR KVKFTQKTIN
     EKLTHILTEF PRMDDIHPFY GDLMHVLYDR DHYKVALGQV GAVRHMVDNV GRDYVRLLKY
     GDSLYRCKQL KRAALGRMAT ACKKLTSALV YLEKVRQHMS RLPSIDPNAR TLLITGFPNV
     GKSSFMNKVT RADVEVQPYA FTTKSLFVGH TDFKYASWQV IDTPGILDHS LEERNVIEMQ
     AITALAHLRA CILFFMDLST QCGHSIAQQV SLFKSIGPLF TGKPVIVVFN KSDLCTFDDI
     TAEEQSLVMT AIEECGAKWI TTSTLTDAGV GDLKTLACET LLAHRSEQKE GSGRFQAIQN
     RLYCAVPQKR DNVERPAYVP PSVEEIRQRL ASGEPVRERR KTERDYEWEN GGPGQYQPNE
     RKTWDLENPE WVDDIIPDIM DGHNIYDNVD PDIHERLMEL EAEEDARLQE LELEASKKRP
     QYELHDSTVE AVRFIRDKIK VIKMERAMKN PSLRRTRRQS VAIEKFNKRT GSQVDRSATP
     GCSSETTNSS AKRGRSLSAA QEAVMRDRSS SHMSTKTTRG ISSHSATRDR SLSVNRGEGY
     RDVNEKLRAV KLSKVVARPR NLQAKKGEGD RAIPNLRPKH LFTGKVKSNG RRDRR