ID   NOG2_ASHGO              Reviewed;         502 AA.
AC   Q75DA4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Nucleolar GTP-binding protein 2;
GN   Name=NOG2; OrderedLocusNames=ABR120C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC       nucleolus and is required for their nuclear export and maturation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; AE016815; AAS50891.1; -; Genomic_DNA.
DR   RefSeq; NP_983067.1; NM_208420.1.
DR   AlphaFoldDB; Q75DA4; -.
DR   SMR; Q75DA4; -.
DR   STRING; 33169.AAS50891; -.
DR   PRIDE; Q75DA4; -.
DR   EnsemblFungi; AAS50891; AAS50891; AGOS_ABR120C.
DR   GeneID; 4619174; -.
DR   KEGG; ago:AGOS_ABR120C; -.
DR   eggNOG; KOG2423; Eukaryota.
DR   HOGENOM; CLU_011106_4_0_1; -.
DR   InParanoid; Q75DA4; -.
DR   OMA; PAPFQGR; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:2000200; P:regulation of ribosomal subunit export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR024929; NOG2.
DR   InterPro; IPR012971; NOG2_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11089:SF9; PTHR11089:SF9; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08153; NGP1NT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..502
FT                   /note="Nucleolar GTP-binding protein 2"
FT                   /id="PRO_0000215808"
FT   DOMAIN          211..372
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         321..328
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         365..369
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   502 AA;  56993 MW;  89F55F5CBB211F46 CRC64;
     MGTAKKEQQR RIREGNTKDG NLRVKGENFY RDGKRVKFLN MYKGGKSIRN AKGDLIRAAP
     LQSTDVPTAR VQPDRRWFGN TRVISQDALQ HFRDALGDKK NDSYQVLLRR NKLPMSLLEE
     KDTSESPTAK IIDTEPYGAT FGPKAQRKKP RVAAASLEDL AKATDSDSQK YEEKKELDST
     LGLMAATEQE DGWSQVAKEA IFHKGQSKRI WNELYKVIDS SDVVIHVLDA RDPLGTRCKS
     VEEYMKKETP HKHLIYVLNK CDLVPTWLAA AWVKHLSKDR PTLAFHASIT NSFGKGSLIQ
     LLRQFSQLHK DRQQISVGFI GYPNTGKSSI INTLRKKKVC QVAPIPGETK VWQYITLMKR
     IFLIDCPGIV PPSAKDTEED ILFRGVVRVE HVSHPEQYIP AVLRRCKRHH LERTYEISGW
     ADATEFIEML ARKQGRLLKG GEPDETGVAK QVLNDFNRGK IPWFVSPPDR DPQPETSKRP
     ADSEPETAQE APEPPANKRL RV