ID   NOG2_CANGA              Reviewed;         494 AA.
AC   Q6FWS1;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Nucleolar GTP-binding protein 2;
GN   Name=NOG2; OrderedLocusNames=CAGL0C03369;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC       nucleolus and is required for their nuclear export and maturation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; CR380949; CAG58229.1; -; Genomic_DNA.
DR   RefSeq; XP_445323.1; XM_445323.1.
DR   AlphaFoldDB; Q6FWS1; -.
DR   SMR; Q6FWS1; -.
DR   STRING; 5478.XP_445323.1; -.
DR   PRIDE; Q6FWS1; -.
DR   EnsemblFungi; CAG58229; CAG58229; CAGL0C03369g.
DR   GeneID; 2886741; -.
DR   KEGG; cgr:CAGL0C03369g; -.
DR   CGD; CAL0127296; CAGL0C03369g.
DR   VEuPathDB; FungiDB:CAGL0C03369g; -.
DR   eggNOG; KOG2423; Eukaryota.
DR   HOGENOM; CLU_011106_4_0_1; -.
DR   InParanoid; Q6FWS1; -.
DR   OMA; PAPFQGR; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:2000200; P:regulation of ribosomal subunit export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR024929; NOG2.
DR   InterPro; IPR012971; NOG2_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11089:SF9; PTHR11089:SF9; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08153; NGP1NT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..494
FT                   /note="Nucleolar GTP-binding protein 2"
FT                   /id="PRO_0000215809"
FT   DOMAIN          212..373
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         322..329
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         366..370
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   494 AA;  56826 MW;  F6DE63440029E066 CRC64;
     MGTGKKEKQR RIREGTTKDG NIRVKGENFY RDSKRVQFLN MYKSGKAIKN KHGDVIRAAD
     YQDTTIPDAR VQPDRRWFGN TRVISQDALQ HFRDALGETQ KDTYQVLLRR NKLPMSLLDE
     KDSTESPRAR ILETESFDQT FGPKAQRKKP RVAASSLEEL VQATEEENKT YEEKEELKAT
     LGLMGKQEDE ENGWTQVTKE AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK
     SVEEYMKKET PHKHLIYVLN KCDLVPTWVA AAWVKHLSKD RPTLAFHASI TNSFGKGSLI
     QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET KVWQYITLMK
     RIFLIDCPGI VPPSTKDSEE DILFRGVVRV EHVSHPEQYI PGVLKRCQTK HLERTYEISG
     WKDATDFIEM LARKQGRLLK GGEPDESGVS KQILNDFNRG KIPWFVIPPE KEEDKKRKLD
     EEEVKSAKMQ KVKD