ID   NOG2_CRYGA              Reviewed;         731 AA.
AC   Q6TGJ8;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Nucleolar GTP-binding protein 2;
GN   Name=NOG2;
OS   Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=552467;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 32609 / CBS 6956 / NIH 444 / Serotype B;
RX   PubMed=15567176; DOI=10.1016/j.bbrc.2004.11.017;
RA   Ren P., Roncaglia P., Springer D.J., Fan J., Chaturvedi V.;
RT   "Genomic organization and expression of 23 new genes from MATalpha locus of
RT   Cryptococcus neoformans var. gattii.";
RL   Biochem. Biophys. Res. Commun. 326:233-241(2005).
CC   -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC       nucleolus and is required for their nuclear export and maturation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; AY421966; AAS92523.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6TGJ8; -.
DR   SMR; Q6TGJ8; -.
DR   VEuPathDB; FungiDB:CGB_I1220W; -.
DR   VEuPathDB; FungiDB:CNBG_5856; -.
DR   VEuPathDB; FungiDB:I306_06620; -.
DR   VEuPathDB; FungiDB:I308_03660; -.
DR   VEuPathDB; FungiDB:I311_03673; -.
DR   VEuPathDB; FungiDB:I314_03638; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR024929; NOG2.
DR   InterPro; IPR012971; NOG2_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11089:SF9; PTHR11089:SF9; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08153; NGP1NT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Ribosome biogenesis.
FT   CHAIN           1..731
FT                   /note="Nucleolar GTP-binding protein 2"
FT                   /id="PRO_0000215810"
FT   DOMAIN          223..396
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..654
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..680
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        699..731
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         345..352
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         389..393
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   731 AA;  81231 MW;  7358C99B522EDAEC CRC64;
     MGKGKNHDRK ANPGFGKVKS KSGTSTGEFT LKRVKGENFY RDAKSAARVK MLNGGKAVRD
     RDGKIVEAAA FQKGEKEAEP GRVKPDRRWF GNTRVISQSA LDHFRTALKE QKADPYSVLL
     KRNKLPMGLL QDDTKDSGSR PHIVETEPFG DTFGPKAQRK RPRLDIGSIE ELGESSAAAA
     TAAEAATAES QANGTADLAD IYHPTTSTAR EPIYAKGTSR RIWGELYKVL DSSDVVIHVL
     DARDPLGTRC KPVVEYLRKE KAHKHLVYVL NKVDLVPTWV TSGPYAYAYA NGPARWVKHL
     SLSAPTIAFH ASINNSFGKG SLIQLLRQFS VLHSDKKQIS VGFIGYPNTG KSSIINTLKK
     KKVCTVAPIP GETKVWQYIT LMRRIYLIDC PGIVPVSAKD SDTDTVLKGV VRVENLATPA
     EHIPALLERV RPEYLERTYN LEHVEGGWHG EQGATVILTA IAKKSGKLLK GGEPDQEAAA
     KMVLNDWIRG KIPFFVAPPA KSEPGAPTAA TAAAATTTEA EKKKTEAEEQ ELAEERETME
     ILEEQERSLG KVLGIKRVKG VEQPISKIVT MTKFIGDDAR RYVEEEEVVD QDKEMVEKEE
     EEEEEEDEDE DEEEEELAWE DVFPEEADAV DGGEEVEESD KEETDDEEDV DEEEAVPSAK
     QLGKRKAIDS DEEEQTANKS KRMTTNKQKA TNFYTHANVK NRNRDRKVPK NPGKRSRGDD
     ETTGKKAKKR R