ID   NOG2_PNECA              Reviewed;         483 AA.
AC   Q9C3Z4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Nucleolar GTP-binding protein 2;
DE   AltName: Full=Binding-inducible GTPase;
GN   Name=NOG2;
OS   Pneumocystis carinii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
OX   NCBI_TaxID=4754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kottom T.J., Limper A.H.;
RT   "Gene activation induced by binding to mammalian surfaces and alveolar
RT   cells.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC       nucleolus and is required for their nuclear export and maturation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; AF332387; AAK06843.1; -; mRNA.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR024929; NOG2.
DR   InterPro; IPR012971; NOG2_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11089:SF9; PTHR11089:SF9; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08153; NGP1NT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Ribosome biogenesis.
FT   CHAIN           1..483
FT                   /note="Nucleolar GTP-binding protein 2"
FT                   /id="PRO_0000215814"
FT   DOMAIN          189..350
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   BINDING         299..306
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         343..347
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  55552 MW;  97504E3EF5B33030 CRC64;
     MCCKAIKLGN ARVFPVTTFR DAKKVRWINL LKSGKAKRNK SGKIIKQGEF QSKDVQDARI
     QPYRRWFSNT RVISQDVLNM FRESFAEKLN DPCKVLLKQN KLPMSLLMEP TKTRKANIID
     IEPFDDTFGK KSXRKRAKLY ASSIENLSNF AFESYENYIK KNSEYENVDK NIQKSFEAIF
     SKGTSKRIWN ELYKXIDSSD VIIQLLDARN PLGTRCKHVE EYLKKEKPHK HMILLLNKCD
     LIPTWCTREW IKQLSKEYPT LAFHASINNP FGKGSLIQLL RQFSKLHSNR RQISVGFIGY
     PNTGKSSVIN TLRSKKVCNT APIPGETKVW QYVRMTSKIF MIDCPGIVPP NSNDSETEII
     IKGALRIEKV SNPEQYIHAI LNLCETKHLE RTYQISGWEN DSTKFIELLA RKTGKLLKGG
     EVDESSIAKM VINDFIRGKI PWFIAPAQEN DPSNIKLSNN TLVEKNHLTT LDDEIYNDAN
     PNA