ID   NOG2_YARLI              Reviewed;         509 AA.
AC   Q6C036;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Nucleolar GTP-binding protein 2;
GN   Name=NOG2; OrderedLocusNames=YALI0F28083g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC       nucleolus and is required for their nuclear export and maturation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; CR382132; CAG78788.1; -; Genomic_DNA.
DR   RefSeq; XP_505976.1; XM_505976.1.
DR   AlphaFoldDB; Q6C036; -.
DR   SMR; Q6C036; -.
DR   STRING; 4952.CAG78788; -.
DR   EnsemblFungi; CAG78788; CAG78788; YALI0_F28083g.
DR   GeneID; 2908104; -.
DR   KEGG; yli:YALI0F28083g; -.
DR   VEuPathDB; FungiDB:YALI0_F28083g; -.
DR   HOGENOM; CLU_011106_4_0_1; -.
DR   InParanoid; Q6C036; -.
DR   OMA; HKHKKFR; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR024929; NOG2.
DR   InterPro; IPR012971; NOG2_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11089:SF9; PTHR11089:SF9; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08153; NGP1NT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..509
FT                   /note="Nucleolar GTP-binding protein 2"
FT                   /id="PRO_0000215816"
FT   DOMAIN          204..365
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         314..321
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         358..362
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  57650 MW;  483426AC9FEBE937 CRC64;
     MGTGKKEATR RAKGGETGNG FGNIRVKGVN FYRDAKKVKK LSMYKEGRAK HNARGEEVQA
     ATFQSKEIPN ARIDPNRRWF GNTRVIAQDA LNHFREALGE TKRDSYQVLL RQNKLPMSLL
     EENNKIPQVK VVETESYANT FGPKAQRKKP QLAVGDFAEL ASAADESQQD FEAKKEEDNS
     WKVDGWSQEA KEAIFHKGQS KRIWNELYKV IDSSDVVIHV LDARDPLGTR CTSVEQYIKK
     EAPHKHLIFV LNKCDLVPTW VAAAWVKHLS QDYPTLAFHA SITNSFGKGS LIQLLRQYSA
     LHPDRQQISV GFIGYPNTGK SSIINTLRKK KVCKTAPIPG ETKVWQYITL MKRIFLIDCP
     GIVPPSQKDS ETDILFRGVV RVEHVSYPEQ YIPALLERCE TKHLERTYEV SGWSNATEFL
     EKIARKHGRL LKGGEPDESG IAKLILNDFN RGKIPWFVPP PQAEDMENVK FAAGEGRLGE
     MKKREIHEAP AATETAEETK EEEFKGFDD