ID   NOGG1_DANRE             Reviewed;         216 AA.
AC   Q9W741;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Noggin-1;
DE   Flags: Precursor;
GN   Name=nog1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10491267; DOI=10.1006/dbio.1999.9401;
RA   Fuerthauer M., Thisse B., Thisse C.;
RT   "Three different noggin genes antagonize the activity of bone morphogenetic
RT   proteins in the zebrafish embryo.";
RL   Dev. Biol. 214:181-196(1999).
CC   -!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling. May
CC       play an important role in the dorsoventral patterning of the embryo.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Detected following the activation of the zygotic
CC       genome in a few deep cells of the marginal region of the blastoderm.
CC       From the 5-12 somite stage, expression is observed in the dorsal
CC       telencephalon and in posterior and ventral parts of the eye field. By
CC       the 12-somite stage detected all along the dorsal neural tube from the
CC       level of the diencephalon to the caudal spinal cord and this expression
CC       persists until 24 hours of development. At the 15-somite stage
CC       expression is seen in the midline around the tail bud. Between 15 and
CC       20 hours development dorsal as well as ventral expression is observed
CC       in recently formed somites while in more mature somites, detected only
CC       ventrally. By 24 hours development expression is limited to the ventral
CC       sclerotomal aspect of the caudal somites. Later in development detected
CC       in very restricted parts of the CNS.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; AF159147; AAD43132.1; -; mRNA.
DR   AlphaFoldDB; Q9W741; -.
DR   SMR; Q9W741; -.
DR   STRING; 7955.ENSDARP00000076205; -.
DR   PaxDb; Q9W741; -.
DR   PRIDE; Q9W741; -.
DR   ZFIN; ZDB-GENE-991206-8; nog1.
DR   eggNOG; KOG4485; Eukaryota.
DR   InParanoid; Q9W741; -.
DR   PhylomeDB; Q9W741; -.
DR   PRO; PR:Q9W741; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:ZFIN.
DR   GO; GO:0045202; C:synapse; IDA:ZFIN.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:ZFIN.
DR   GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
DR   GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; PTHR10494; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..216
FT                   /note="Noggin-1"
FT                   /id="PRO_0000019817"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   216 AA;  25093 MW;  3108242F298ABBBE CRC64;
     MDFPRFLLSA YLLLLSFAQC QHYYLLRPIP SDTLPLLELK EDPDPIYDPR EKDLNETELR
     SALGDFDSRF LSVGPPQDRY AGNEDLDEQE LQLNLAGMMP KDIKNLDFDA PWGKKRKASK
     KLKRRLQMWL WSYSFCPVLY AWNDLGSRFW PRFVRAGSCY TKRSCSVPEG MVCKPAKSTH
     ITLLRWRCVA RRGALKCAWI PVQYPIITEC KCSCAN