ID   NOGG2_DANRE             Reviewed;         212 AA.
AC   Q9W740;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Noggin-2;
DE   Flags: Precursor;
GN   Name=nog2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10491267; DOI=10.1006/dbio.1999.9401;
RA   Fuerthauer M., Thisse B., Thisse C.;
RT   "Three different noggin genes antagonize the activity of bone morphogenetic
RT   proteins in the zebrafish embryo.";
RL   Dev. Biol. 214:181-196(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: First appears at the end of gastrulation in the
CC       axial mesoderm. By the 5-somite stage, expressed in telencephalon and
CC       anterior diencephalon. From early segmentation stages until the end of
CC       tail elongation, found in the tail bud. Expression is maintained during
CC       somitogenesis. At the 10-somite stage, detected in the antero-medial
CC       aspect of the somites. At 20 hours of development expression is
CC       observed in the ventro-medial part of the somite as well as in a small
CC       population of cells located more dorsally, adjacent to the neural tube.
CC       As development proceeds, expression in the dorsal somite is
CC       progressively lost, while ventro-medial sclerotomal cells lining the
CC       developing axial vasculature continue to show expression until 30 hours
CC       of development. In the head, expression is maintained in the
CC       telencephalon and anterior diencephalon until late embryogenesis. At
CC       the 15-somite stage, expressed in the forebrain, dorsal hindbrain and
CC       dorsal caudal spinal cord. Until late stages of embryogenesis strong
CC       expression is observed in the dorsal hindbrain walls.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; AF159148; AAD43133.1; -; mRNA.
DR   EMBL; BC056600; AAH56600.1; -; mRNA.
DR   EMBL; BC067541; AAH67541.1; -; mRNA.
DR   RefSeq; NP_571067.1; NM_130992.2.
DR   AlphaFoldDB; Q9W740; -.
DR   SMR; Q9W740; -.
DR   STRING; 7955.ENSDARP00000111870; -.
DR   PaxDb; Q9W740; -.
DR   Ensembl; ENSDART00000063231; ENSDARP00000111870; ENSDARG00000043066.
DR   GeneID; 30185; -.
DR   KEGG; dre:30185; -.
DR   CTD; 30185; -.
DR   ZFIN; ZDB-GENE-991206-14; nog2.
DR   eggNOG; KOG4485; Eukaryota.
DR   GeneTree; ENSGT00390000006009; -.
DR   HOGENOM; CLU_085186_1_0_1; -.
DR   InParanoid; Q9W740; -.
DR   OMA; TYTYCPV; -.
DR   OrthoDB; 1391421at2759; -.
DR   PhylomeDB; Q9W740; -.
DR   TreeFam; TF353745; -.
DR   PRO; PR:Q9W740; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000043066; Expressed in muscle tissue and 23 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:ZFIN.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR   GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; PTHR10494; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..212
FT                   /note="Noggin-2"
FT                   /id="PRO_0000019818"
FT   REGION          37..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  24531 MW;  D0262DD09B9D6504 CRC64;
     MGSITRALPL LLLLLLCAHG TASQHHLRLR PLPSEGLPVP DLIENPDPEH DPREQDLSEK
     TLLKKLGSNF DANFMSIHLP AQLNASAPPE LPRLPMPAEL KKLDLTETPY GRRVKVGKKA
     RRKFLQWLWM YTHCPVLYTW KDLGLRFWPR YIKEGNCFSE RSCSFPEGMS CKPVKAVTKT
     FLRWYCQGFM RQKYCTWIQV QYPIISQCKC SC