ID   NOGG3_DANRE             Reviewed;         223 AA.
AC   Q9YHV3;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Noggin-3;
DE   Flags: Precursor;
GN   Name=nog3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX   PubMed=9882485; DOI=10.1006/dbio.1998.9003;
RA   Bauer H., Meier A., Hild M., Stachel S., Economides A., Hazelett D.,
RA   Harland R.M., Hammerschmidt M.;
RT   "Follistatin and noggin are excluded from the zebrafish organizer.";
RL   Dev. Biol. 204:488-507(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10491267; DOI=10.1006/dbio.1999.9401;
RA   Fuerthauer M., Thisse B., Thisse C.;
RT   "Three different noggin genes antagonize the activity of bone morphogenetic
RT   proteins in the zebrafish embryo.";
RL   Dev. Biol. 214:181-196(1999).
CC   -!- FUNCTION: May function as an inhibitor of bone morphogenetic proteins
CC       (BMP) signaling during later stages of development including late
CC       phases of dorsoventral patterning, to refine the early pattern set up
CC       by the interaction of chordino and BMP2/4. Not involved in organizer
CC       function or early phases of dorsoventral pattern formation.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: Expression is limited to late stages of
CC       embryogenesis. First detected at 48 hours of development and restricted
CC       to regions of ongoing chondrogenesis. Expression is observed in the
CC       ethmoid plate and the trabeculae cranii of the neurocranium as well as
CC       in some presumptive cartilage cells of the pharyngeal arches.
CC       Expression is furthermore observed in the forming cartilage of the
CC       pectoral fins. At 72 hours of development, accumulates in the
CC       ceratobranchial and basibranchial parts of the gill arches.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; AF084949; AAD09176.1; -; mRNA.
DR   RefSeq; NP_571057.1; NM_130982.1.
DR   AlphaFoldDB; Q9YHV3; -.
DR   SMR; Q9YHV3; -.
DR   STRING; 7955.ENSDARP00000103662; -.
DR   PaxDb; Q9YHV3; -.
DR   GeneID; 30173; -.
DR   KEGG; dre:30173; -.
DR   CTD; 30173; -.
DR   ZFIN; ZDB-GENE-990714-8; nog3.
DR   eggNOG; KOG4485; Eukaryota.
DR   InParanoid; Q9YHV3; -.
DR   OrthoDB; 1391421at2759; -.
DR   PhylomeDB; Q9YHV3; -.
DR   Reactome; R-DRE-201451; Signaling by BMP.
DR   PRO; PR:Q9YHV3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0035844; P:cloaca development; IMP:ZFIN.
DR   GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:ZFIN.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR   GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
DR   GO; GO:0048793; P:pronephros development; IMP:ZFIN.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; PTHR10494; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   1: Evidence at protein level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..223
FT                   /note="Noggin-3"
FT                   /id="PRO_0000019819"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   223 AA;  26029 MW;  A21AE5DA36B75A37 CRC64;
     MDNIPYFLAT VLIFSLGFRI EEGMCQHYYL LRPIPSDSLP IVELKEDPDP VLDPKERDLN
     ETELRAILGS HFEQNFMSIN PPEDKHAGQD ELNESELMKQ RPNGIMPKEI KAMEFDIQHG
     KKHKPSKKLR RRLQLWLWSY TFCPVVHTWQ DLGNRFWPRY LKVGSCYNKR SCSVPEGMVC
     KPPKSSHLTV LRWRCVQRKG GLKCAWIPVQ YPVISECKCS CPN