ID   NOGG_CHICK              Reviewed;         223 AA.
AC   O93525; O73674;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Noggin;
DE   AltName: Full=cNoggin;
DE   Flags: Precursor;
GN   Name=NOG;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hamburger-Hamilton; TISSUE=Embryo;
RX   PubMed=9927590; DOI=10.1242/dev.126.5.883;
RA   Pizette S., Niswander L.;
RT   "BMPs negatively regulate structure and function of the limb apical
RT   ectodermal ridge.";
RL   Development 126:883-894(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 54-220.
RX   PubMed=9769170; DOI=10.1006/dbio.1998.8895;
RA   Tonegawa A., Takahashi Y.;
RT   "Somitogenesis controlled by Noggin.";
RL   Dev. Biol. 202:172-182(1998).
CC   -!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling.
CC       Controls somitogenesis by sequestering the BMP-4 activity which in turn
CC       differentiates distinct subtypes of the mesoderm along the mediolateral
CC       axis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DEVELOPMENTAL STAGE: At stage 8 (4-6 somites) expressed in two
CC       prominent regions, the notochord and the one posterior to Hensen node.
CC       At stage 14 (20 somites) expressed in the lateral border of the
CC       segmental plate. As the somite stage proceeds, detected in the lateral
CC       and medial portion of a young and old somite respectively and is also
CC       localized in the notochord and the roof plate of the neural tube.
CC   -!- INDUCTION: By sonic ectopic hedgehog.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; AF057364; AAC83570.1; -; mRNA.
DR   EMBL; AB013493; BAA75065.1; -; mRNA.
DR   RefSeq; NP_989454.1; NM_204123.1.
DR   AlphaFoldDB; O93525; -.
DR   SMR; O93525; -.
DR   STRING; 9031.ENSGALP00000004907; -.
DR   PaxDb; O93525; -.
DR   GeneID; 373912; -.
DR   KEGG; gga:373912; -.
DR   CTD; 9241; -.
DR   VEuPathDB; HostDB:geneid_373912; -.
DR   eggNOG; KOG4485; Eukaryota.
DR   InParanoid; O93525; -.
DR   OrthoDB; 1391421at2759; -.
DR   PhylomeDB; O93525; -.
DR   PRO; PR:O93525; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:UniProtKB.
DR   GO; GO:1902747; P:negative regulation of lens fiber cell differentiation; TAS:AgBase.
DR   GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IMP:UniProtKB.
DR   GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; PTHR10494; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..223
FT                   /note="Noggin"
FT                   /id="PRO_0000019816"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        146..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        169..219
FT                   /evidence="ECO:0000250"
FT   DISULFID        175..221
FT                   /evidence="ECO:0000250"
FT   DISULFID        198..206
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   223 AA;  25596 MW;  085AC7815032849A CRC64;
     MDHSQCLVTI YAAAVLLGLR LQQGSCQHYL HIRPAPSDNL PLVDLIEHPD PIFDPKEKDL
     NETLLRSLMG GHFDPNFMAM SLPEDRLGVD DLAELDLLLR QRPSGAMPGE IKGLEFYDGL
     QPGKKHRLSK KLRRKLQMWL WSQTFCPVLY TWNDLGSRFW PRYVKVGSCY SKRSCSVPEG
     MVCKPAKSVH LTILRWRCQR RGGQRCTWIP IQYPIIAECK CSC