NOGG_RAT
ID NOGG_RAT Reviewed; 144 AA.
AC Q62809;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Noggin;
DE Flags: Precursor; Fragment;
GN Name=Nog;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7666191; DOI=10.1523/jneurosci.15-09-06077.1995;
RA Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., Nunez L., Jones P.,
RA Ip N.Y., Espinosa R. III, Brannan C.I., Gilbert D.J., Copeland N.G.,
RA Jenkins N.A., Le Beau M.M., Harland R.M., Yancopoulos G.D.;
RT "Identification of mammalian noggin and its expression in the adult nervous
RT system.";
RL J. Neurosci. 15:6077-6084(1995).
CC -!- FUNCTION: Essential for cartilage morphogenesis and joint formation.
CC Inhibitor of bone morphogenetic proteins (BMP) signaling which is
CC required for growth and patterning of the neural tube and somite (By
CC similarity). Inhibits chondrocyte differentiation through its
CC interaction with GDF5 and, probably, GDF6 (By similarity).
CC {ECO:0000250|UniProtKB:P97466, ECO:0000250|UniProtKB:Q13253}.
CC -!- SUBUNIT: Homodimer. Interacts with GDF5; inhibits chondrocyte
CC differentiation. {ECO:0000250|UniProtKB:Q13253}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Prominently expressed in the CNS. High levels found
CC in mitral and tufted cells in the olfactory bulb, piriform cortex of
CC the brain and Purkinje cells in the cerebellum. Low level expression
CC seen in the lung, skeletal muscle and skin.
CC -!- DEVELOPMENTAL STAGE: First detected at embryonic day 9 and in the
CC brain, expression increases steadily from embryonic day 17 to postnatal
CC day 19.
CC -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR EMBL; U31203; AAA83260.1; -; mRNA.
DR AlphaFoldDB; Q62809; -.
DR SMR; Q62809; -.
DR STRING; 10116.ENSRNOP00000030212; -.
DR PaxDb; Q62809; -.
DR RGD; 3183; Nog.
DR eggNOG; KOG4485; Eukaryota.
DR InParanoid; Q62809; -.
DR PhylomeDB; Q62809; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR GO; GO:0019955; F:cytokine binding; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISO:RGD.
DR GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; ISO:RGD.
DR GO; GO:0048318; P:axial mesoderm development; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
DR GO; GO:0061312; P:BMP signaling pathway involved in heart development; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0021533; P:cell differentiation in hindbrain; ISO:RGD.
DR GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR GO; GO:0071773; P:cellular response to BMP stimulus; IEP:RGD.
DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR GO; GO:0007417; P:central nervous system development; ISO:RGD.
DR GO; GO:1904888; P:cranial skeletal system development; ISO:RGD.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:RGD.
DR GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR GO; GO:0003203; P:endocardial cushion morphogenesis; ISO:RGD.
DR GO; GO:0007492; P:endoderm development; ISO:RGD.
DR GO; GO:0001706; P:endoderm formation; ISO:RGD.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.
DR GO; GO:0035640; P:exploration behavior; ISO:RGD.
DR GO; GO:0060325; P:face morphogenesis; ISO:RGD.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; IEP:RGD.
DR GO; GO:0061384; P:heart trabecula morphogenesis; ISO:RGD.
DR GO; GO:0021766; P:hippocampus development; IEP:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0060291; P:long-term synaptic potentiation; ISO:RGD.
DR GO; GO:0060425; P:lung morphogenesis; ISO:RGD.
DR GO; GO:0003149; P:membranous septum morphogenesis; ISO:RGD.
DR GO; GO:0007613; P:memory; IMP:RGD.
DR GO; GO:0048762; P:mesenchymal cell differentiation; IMP:RGD.
DR GO; GO:0001707; P:mesoderm formation; ISO:RGD.
DR GO; GO:0042474; P:middle ear morphogenesis; ISO:RGD.
DR GO; GO:0008045; P:motor neuron axon guidance; ISO:RGD.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IMP:RGD.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; ISS:UniProtKB.
DR GO; GO:0061037; P:negative regulation of cartilage development; ISO:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
DR GO; GO:0060302; P:negative regulation of cytokine activity; ISO:RGD.
DR GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:RGD.
DR GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0001839; P:neural plate morphogenesis; ISO:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0021915; P:neural tube development; ISO:RGD.
DR GO; GO:0048570; P:notochord morphogenesis; ISO:RGD.
DR GO; GO:0001503; P:ossification; IEP:RGD.
DR GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISO:RGD.
DR GO; GO:0007389; P:pattern specification process; ISO:RGD.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISO:RGD.
DR GO; GO:0021983; P:pituitary gland development; ISO:RGD.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0090193; P:positive regulation of glomerulus development; ISS:UniProtKB.
DR GO; GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IMP:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; ISO:RGD.
DR GO; GO:0060513; P:prostatic bud formation; ISO:RGD.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; ISO:RGD.
DR GO; GO:2000313; P:regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; ISO:RGD.
DR GO; GO:0048168; P:regulation of neuronal synaptic plasticity; ISO:RGD.
DR GO; GO:1990926; P:short-term synaptic potentiation; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR GO; GO:0035019; P:somatic stem cell population maintenance; ISO:RGD.
DR GO; GO:0061053; P:somite development; ISO:RGD.
DR GO; GO:0021510; P:spinal cord development; ISO:RGD.
DR GO; GO:0001657; P:ureteric bud development; ISO:RGD.
DR GO; GO:0060676; P:ureteric bud formation; ISO:RGD.
DR GO; GO:0001655; P:urogenital system development; ISO:RGD.
DR GO; GO:0003223; P:ventricular compact myocardium morphogenesis; ISO:RGD.
DR GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
DR GO; GO:0008542; P:visual learning; IMP:RGD.
DR GO; GO:0042060; P:wound healing; IEP:RGD.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR008717; Noggin.
DR PANTHER; PTHR10494; PTHR10494; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 2: Evidence at transcript level;
KW Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL <1..4
FT /evidence="ECO:0000255"
FT CHAIN 5..144
FT /note="Noggin"
FT /id="PRO_0000019815"
FT DISULFID 67..104
FT /evidence="ECO:0000250"
FT DISULFID 90..140
FT /evidence="ECO:0000250"
FT DISULFID 96..142
FT /evidence="ECO:0000250"
FT DISULFID 119..127
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 144 AA; 16139 MW; 53BBE432B0D7298D CRC64;
GGGGGPAGGA EDLAELDQLL RQRPSGAMPS EIKGLEFSEG LAQGKKQRLS KKLRRKLQMW
LWSQTFCPVL YAWNDLGSRF WARYVKVGSC FSKRSCSVPE GMVCKPSKSV HLTVLRWRCQ
RRGGQRCGWI PIQYPIISEC KCSC
