ID   NOGG_TAKRU              Reviewed;         223 AA.
AC   Q9YHT8;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Noggin;
DE   Flags: Precursor;
GN   Name=nog;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9882485; DOI=10.1006/dbio.1998.9003;
RA   Bauer H., Meier A., Hild M., Stachel S., Economides A., Hazelett D.,
RA   Harland R.M., Hammerschmidt M.;
RT   "Follistatin and noggin are excluded from the zebrafish organizer.";
RL   Dev. Biol. 204:488-507(1998).
CC   -!- FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; AF095337; AAC72965.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9YHT8; -.
DR   SMR; Q9YHT8; -.
DR   STRING; 31033.ENSTRUP00000006286; -.
DR   eggNOG; KOG4485; Eukaryota.
DR   InParanoid; Q9YHT8; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:InterPro.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; PTHR10494; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..223
FT                   /note="Noggin"
FT                   /id="PRO_0000019820"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        143..180
FT                   /evidence="ECO:0000250"
FT   DISULFID        166..217
FT                   /evidence="ECO:0000250"
FT   DISULFID        172..219
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..204
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   223 AA;  25121 MW;  35CE122E1B27F729 CRC64;
     MDPPRLRVAT YLLLLSVGLL LHGGACQPYY LLRPIPSDSL PIVELKEDPG PVFDPKERDL
     NETELKSVLG DFDSRFLSVL PPAEDGHAGN DELDDFDAQR WGGALPKEIR AVDFDAPQLG
     KKHKPSKKLK RRLQQWLWAY SFCPLAHAWT DLGSRFWPRF VRAGSCLSKR SCSVPEGMTC
     KPATSTHLTI LRWRCVQRKV GLKCAWIPMQ YPVITDCKCS CSG