ID   NOL10_CHATD             Reviewed;         668 AA.
AC   G0S902;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Ribosome biogenesis protein ENP2;
GN   Name=ENP2; ORFNames=CTHT_0044060;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: May be involved in rRNA-processing and ribosome biosynthesis.
CC       {ECO:0000250|UniProtKB:P48234}.
CC   -!- SUBUNIT: Component of the 90S pre-ribosomes.
CC       {ECO:0000250|UniProtKB:P48234}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P48234}.
CC   -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS19913.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL988043; EGS19913.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006694798.1; XM_006694735.1.
DR   PDB; 6RXU; EM; 3.50 A; CW=1-668.
DR   PDB; 6RXV; EM; 4.00 A; CW=1-668.
DR   PDB; 6RXX; EM; 7.10 A; CW=1-668.
DR   PDB; 6RXZ; EM; 4.40 A; CW=1-668.
DR   PDBsum; 6RXU; -.
DR   PDBsum; 6RXV; -.
DR   PDBsum; 6RXX; -.
DR   PDBsum; 6RXZ; -.
DR   AlphaFoldDB; G0S902; -.
DR   SMR; G0S902; -.
DR   STRING; 759272.G0S902; -.
DR   EnsemblFungi; EGS19913; EGS19913; CTHT_0044060.
DR   GeneID; 18258444; -.
DR   KEGG; cthr:CTHT_0044060; -.
DR   eggNOG; KOG2321; Eukaryota.
DR   HOGENOM; CLU_009923_0_1_1; -.
DR   OrthoDB; 1099332at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR040382; NOL10/Enp2.
DR   InterPro; IPR012580; NUC153.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14927; PTHR14927; 1.
DR   Pfam; PF08159; NUC153; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   rRNA processing; WD repeat.
FT   CHAIN           1..668
FT                   /note="Ribosome biogenesis protein ENP2"
FT                   /id="PRO_0000435816"
FT   REPEAT          199..239
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          242..281
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          288..326
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          328..367
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          409..450
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REGION          518..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..595
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..624
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..668
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  75714 MW;  6440C2502C4004E0 CRC64;
     MKLTNPGPVP VYTVAGPSTA RPLPDWLLRR RKRSAKYDPE NLNNFELIQE FEFEEASNCV
     RVSEDGNWIM STGTYKPQFH VHNTRELSLS FSRHTNSENV TFLLLSQDYS KSVHLQCDRT
     LEFHTPMGCH YSIRIPRFGR DLAYLRQSCE VLVPAVGLSS DGSGYGEVFR LDLERGQFLR
     PWQVDVGEDE PGSGLQGSIH AGAVNVAAVA ENTHGLCAFG TSIGTVEFYD PRSKSRVAVL
     GNQDGEITAL DYSRDGLSLA LGTSTGQIRI FDLRNPRPLL KKDQGMGLPI KNLIHLTTPT
     EERKLLSADK RIIKIWDEQS GDLWTSVEPL VDLNFVTHVP DSGMILTANE GKQMHCFFIP
     NLGLAPRWCH FLDNLVHEME SEKRTETYDN YKFLTKPELK SLSLDHLIGK TNLLRPYMHG
     FFVHAKLYDQ ARLITNPYIW EEERAKRIKE KIEKERSSRI RGIKKVKVNQ KLVEKIAERQ
     EKKGKPDVAA AMLQDPRFGK LFEDEEFAVD ETSREFRALN PSTKIPGAQG DQDGDVKMGD
     FSSEEESSEG SGSEDEREPR RENKKPEKPK EKPKKVEEPK KHEASKPKDE VVMQIRSSKE
     QGGKLGDTAF GEREQKDTRA SRIRTGEVVG EQVLTFIPES KKKKPQPAPE TKPRTDRRSA
     SNNALRKL