NOL10_DANRE
ID NOL10_DANRE Reviewed; 722 AA.
AC Q802W4; Q6TNU2;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Nucleolar protein 10;
GN Name=nol10; ORFNames=zgc:55626;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
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DR EMBL; AY391425; AAQ91237.1; -; mRNA.
DR EMBL; BC047174; AAH47174.1; -; mRNA.
DR RefSeq; NP_956531.1; NM_200237.1.
DR AlphaFoldDB; Q802W4; -.
DR SMR; Q802W4; -.
DR STRING; 7955.ENSDARP00000018924; -.
DR PaxDb; Q802W4; -.
DR PRIDE; Q802W4; -.
DR GeneID; 393206; -.
DR KEGG; dre:393206; -.
DR CTD; 79954; -.
DR ZFIN; ZDB-GENE-040426-764; nol10.
DR eggNOG; KOG2321; Eukaryota.
DR InParanoid; Q802W4; -.
DR OrthoDB; 1099332at2759; -.
DR PhylomeDB; Q802W4; -.
DR PRO; PR:Q802W4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR040382; NOL10/Enp2.
DR InterPro; IPR012580; NUC153.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR PANTHER; PTHR14927; PTHR14927; 1.
DR Pfam; PF08159; NUC153; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50998; SSF50998; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..722
FT /note="Nucleolar protein 10"
FT /id="PRO_0000051104"
FT REPEAT 50..90
FT /note="WD 1"
FT REPEAT 174..213
FT /note="WD 2"
FT REPEAT 228..266
FT /note="WD 3"
FT REPEAT 270..308
FT /note="WD 4"
FT REPEAT 310..349
FT /note="WD 5"
FT REGION 521..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..476
FT /evidence="ECO:0000255"
FT COILED 511..534
FT /evidence="ECO:0000255"
FT COILED 620..681
FT /evidence="ECO:0000255"
FT COMPBIAS 526..550
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 197
FT /note="E -> K (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 211..213
FT /note="VAA -> AAV (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="D -> E (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="R -> H (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 603
FT /note="K -> Q (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 703
FT /note="G -> R (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="G -> D (in Ref. 1; AAQ91237)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 722 AA; 83581 MW; 58DDE88997133683 CRC64;
MQVSSVNNVK IYNLSHGKSL PEWLSDRKKR VLQKKDVDIQ RRIELIQDFE MPTVCTSIRV
SRDGQYILAA GTYKPRVRCY DTYQLSLKFE RCLDSDVVTF DILSDDYSKL VFLHIDRYVE
FHSQHGHYYK TRIPKFGRDF SYHSPSCDLY FVGASSEVFR LNLEQGRFLN SLQTDAAEMN
VCDINPVHQL FAAGTLEGRV DCWDPRVRTR VAALDCALSS ITDNTEVEGL PSVSALKFND
SLGLAVGTST GQILVYDLRS SRPLLVKDHY YGLPIKSLHF HNSLDLVLSA DSKIIKMWNK
DNGKVFSSIE PQANINDVCL YPASGMLFTA NEDPKMNTFY IPALGPAPRW CSFLDNLTEE
LEENPESTIY DDYKFVTRKD LESLGLAHLI GSPLLRAYMH GFFMDIRLYH KVKTMVNPFA
YEEYRKDKIR QKIEESRAQR VQLKKLPKVN KELALKLMEE DTELTNKKKK KKANVAGNLL
MDDRFKVMFE NPDYQVDERS EEFRLLNPII SNVAERRRKS LLEEEQEQAE EEQEPEGRGS
SEDDSSDEDD KGWVQEVREQ RRLLRMEERE RSYIQRQERR QQDRNTRLQS SDTHTQQSHG
AQKPRFYQIK SGEEFRSFSD VSRKQKTHKA SLEERLQRLE KSDTLSLNDT AVGSKQLTFT
LKKTEKQRFQ QQAERDHHEE RRRIRRSAGH LHSNRGGGRG RGGGRGRGGG RGRGGGRGRR
PF
