NOL10_MOUSE
ID NOL10_MOUSE Reviewed; 687 AA.
AC Q5RJG1;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Nucleolar protein 10;
GN Name=Nol10; Synonyms=Gm67;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
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DR EMBL; BC086676; AAH86676.1; -; mRNA.
DR CCDS; CCDS25828.1; -.
DR RefSeq; NP_001008421.1; NM_001008421.1.
DR AlphaFoldDB; Q5RJG1; -.
DR SMR; Q5RJG1; -.
DR BioGRID; 229915; 5.
DR STRING; 10090.ENSMUSP00000035930; -.
DR iPTMnet; Q5RJG1; -.
DR PhosphoSitePlus; Q5RJG1; -.
DR EPD; Q5RJG1; -.
DR MaxQB; Q5RJG1; -.
DR PaxDb; Q5RJG1; -.
DR PRIDE; Q5RJG1; -.
DR ProteomicsDB; 293870; -.
DR Antibodypedia; 26703; 104 antibodies from 20 providers.
DR DNASU; 217431; -.
DR Ensembl; ENSMUST00000046011; ENSMUSP00000035930; ENSMUSG00000061458.
DR GeneID; 217431; -.
DR KEGG; mmu:217431; -.
DR UCSC; uc007ncu.1; mouse.
DR CTD; 79954; -.
DR MGI; MGI:2684913; Nol10.
DR VEuPathDB; HostDB:ENSMUSG00000061458; -.
DR eggNOG; KOG2321; Eukaryota.
DR GeneTree; ENSGT00390000007900; -.
DR HOGENOM; CLU_009923_2_0_1; -.
DR InParanoid; Q5RJG1; -.
DR OMA; GEWVMST; -.
DR OrthoDB; 1099332at2759; -.
DR PhylomeDB; Q5RJG1; -.
DR TreeFam; TF105808; -.
DR BioGRID-ORCS; 217431; 27 hits in 71 CRISPR screens.
DR ChiTaRS; Nol10; mouse.
DR PRO; PR:Q5RJG1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q5RJG1; protein.
DR Bgee; ENSMUSG00000061458; Expressed in animal zygote and 201 other tissues.
DR ExpressionAtlas; Q5RJG1; baseline and differential.
DR Genevisible; Q5RJG1; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR040382; NOL10/Enp2.
DR InterPro; IPR012580; NUC153.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14927; PTHR14927; 1.
DR Pfam; PF08159; NUC153; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..687
FT /note="Nucleolar protein 10"
FT /id="PRO_0000051102"
FT REPEAT 50..90
FT /note="WD 1"
FT REPEAT 174..213
FT /note="WD 2"
FT REPEAT 228..266
FT /note="WD 3"
FT REPEAT 270..308
FT /note="WD 4"
FT REPEAT 310..349
FT /note="WD 5"
FT REGION 526..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..476
FT /evidence="ECO:0000255"
FT COILED 514..588
FT /evidence="ECO:0000255"
FT COILED 639..672
FT /evidence="ECO:0000255"
FT COMPBIAS 542..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..687
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT MOD_RES 475
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT MOD_RES 481
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT MOD_RES 514
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSC4"
SQ SEQUENCE 687 AA; 80077 MW; E9ED629E66B78FF6 CRC64;
MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKNVDVR RRIELIQDFE MPTVCTTIKV
SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF EILSDDYSKI VFLHNDRYIE
FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY FVGASSEVYR LNLEQGRYLN PLQTDAAENN
VCDINAVHGL FATGTIEGRV ECWDPRVRKR VGVLDCALNS VTADSEINSL PTISALKFNG
ALSMAVGTST GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLVLSA DSRIVKMWNK
DSGKIFTSLE PEHDLNDVCL YPSSGMLLTA NESPKMGIYY IPVLGPAPRW CSFLDNLTEE
LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH GFFMDIRLYH KVKLMVNPFA
YEEYRKDKIR QKIEETRAQR VQLKKLPKVN KELALKLIEE EEEKQKSTLK KKVKSLPNIL
TDDRFKVMFE NPDFQVDEES EEFRLLNPLV SRISEKRKKQ LRLLEQQELK DEEEEEPEGK
PSDAESSESS DDEKGWVEEV RKQRRLLQQE ERVKRQEQLK EDQQTVLKPQ FYEIKAGEEF
RSFKESATKQ RLMNKTLEDR LKLEAKHGTL NVSDTTVGSK QLTFTLKRSE QQKKQQEAEK
LHRQERKNLR RSASHLRSRP RRGRPFH