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NOL10_MOUSE
ID   NOL10_MOUSE             Reviewed;         687 AA.
AC   Q5RJG1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Nucleolar protein 10;
GN   Name=Nol10; Synonyms=Gm67;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
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DR   EMBL; BC086676; AAH86676.1; -; mRNA.
DR   CCDS; CCDS25828.1; -.
DR   RefSeq; NP_001008421.1; NM_001008421.1.
DR   AlphaFoldDB; Q5RJG1; -.
DR   SMR; Q5RJG1; -.
DR   BioGRID; 229915; 5.
DR   STRING; 10090.ENSMUSP00000035930; -.
DR   iPTMnet; Q5RJG1; -.
DR   PhosphoSitePlus; Q5RJG1; -.
DR   EPD; Q5RJG1; -.
DR   MaxQB; Q5RJG1; -.
DR   PaxDb; Q5RJG1; -.
DR   PRIDE; Q5RJG1; -.
DR   ProteomicsDB; 293870; -.
DR   Antibodypedia; 26703; 104 antibodies from 20 providers.
DR   DNASU; 217431; -.
DR   Ensembl; ENSMUST00000046011; ENSMUSP00000035930; ENSMUSG00000061458.
DR   GeneID; 217431; -.
DR   KEGG; mmu:217431; -.
DR   UCSC; uc007ncu.1; mouse.
DR   CTD; 79954; -.
DR   MGI; MGI:2684913; Nol10.
DR   VEuPathDB; HostDB:ENSMUSG00000061458; -.
DR   eggNOG; KOG2321; Eukaryota.
DR   GeneTree; ENSGT00390000007900; -.
DR   HOGENOM; CLU_009923_2_0_1; -.
DR   InParanoid; Q5RJG1; -.
DR   OMA; GEWVMST; -.
DR   OrthoDB; 1099332at2759; -.
DR   PhylomeDB; Q5RJG1; -.
DR   TreeFam; TF105808; -.
DR   BioGRID-ORCS; 217431; 27 hits in 71 CRISPR screens.
DR   ChiTaRS; Nol10; mouse.
DR   PRO; PR:Q5RJG1; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q5RJG1; protein.
DR   Bgee; ENSMUSG00000061458; Expressed in animal zygote and 201 other tissues.
DR   ExpressionAtlas; Q5RJG1; baseline and differential.
DR   Genevisible; Q5RJG1; MM.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR040382; NOL10/Enp2.
DR   InterPro; IPR012580; NUC153.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14927; PTHR14927; 1.
DR   Pfam; PF08159; NUC153; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..687
FT                   /note="Nucleolar protein 10"
FT                   /id="PRO_0000051102"
FT   REPEAT          50..90
FT                   /note="WD 1"
FT   REPEAT          174..213
FT                   /note="WD 2"
FT   REPEAT          228..266
FT                   /note="WD 3"
FT   REPEAT          270..308
FT                   /note="WD 4"
FT   REPEAT          310..349
FT                   /note="WD 5"
FT   REGION          526..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          423..476
FT                   /evidence="ECO:0000255"
FT   COILED          514..588
FT                   /evidence="ECO:0000255"
FT   COILED          639..672
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        542..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..666
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..687
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         475
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         481
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         514
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
SQ   SEQUENCE   687 AA;  80077 MW;  E9ED629E66B78FF6 CRC64;
     MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKNVDVR RRIELIQDFE MPTVCTTIKV
     SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF EILSDDYSKI VFLHNDRYIE
     FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY FVGASSEVYR LNLEQGRYLN PLQTDAAENN
     VCDINAVHGL FATGTIEGRV ECWDPRVRKR VGVLDCALNS VTADSEINSL PTISALKFNG
     ALSMAVGTST GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLVLSA DSRIVKMWNK
     DSGKIFTSLE PEHDLNDVCL YPSSGMLLTA NESPKMGIYY IPVLGPAPRW CSFLDNLTEE
     LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH GFFMDIRLYH KVKLMVNPFA
     YEEYRKDKIR QKIEETRAQR VQLKKLPKVN KELALKLIEE EEEKQKSTLK KKVKSLPNIL
     TDDRFKVMFE NPDFQVDEES EEFRLLNPLV SRISEKRKKQ LRLLEQQELK DEEEEEPEGK
     PSDAESSESS DDEKGWVEEV RKQRRLLQQE ERVKRQEQLK EDQQTVLKPQ FYEIKAGEEF
     RSFKESATKQ RLMNKTLEDR LKLEAKHGTL NVSDTTVGSK QLTFTLKRSE QQKKQQEAEK
     LHRQERKNLR RSASHLRSRP RRGRPFH
 
 
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