ID   NOL10_RAT               Reviewed;         688 AA.
AC   Q66H99;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Nucleolar protein 10;
GN   Name=Nol10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
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DR   EMBL; BC081954; AAH81954.1; -; mRNA.
DR   RefSeq; NP_001014098.1; NM_001014076.1.
DR   AlphaFoldDB; Q66H99; -.
DR   SMR; Q66H99; -.
DR   STRING; 10116.ENSRNOP00000007169; -.
DR   PaxDb; Q66H99; -.
DR   PRIDE; Q66H99; -.
DR   Ensembl; ENSRNOT00000007169; ENSRNOP00000007169; ENSRNOG00000005344.
DR   GeneID; 313981; -.
DR   KEGG; rno:313981; -.
DR   CTD; 79954; -.
DR   RGD; 1359447; Nol10.
DR   eggNOG; KOG2321; Eukaryota.
DR   GeneTree; ENSGT00390000007900; -.
DR   HOGENOM; CLU_009923_2_0_1; -.
DR   InParanoid; Q66H99; -.
DR   OMA; GEWVMST; -.
DR   OrthoDB; 1099332at2759; -.
DR   PhylomeDB; Q66H99; -.
DR   TreeFam; TF105808; -.
DR   PRO; PR:Q66H99; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000005344; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q66H99; RN.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR040382; NOL10/Enp2.
DR   InterPro; IPR012580; NUC153.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14927; PTHR14927; 1.
DR   Pfam; PF08159; NUC153; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..688
FT                   /note="Nucleolar protein 10"
FT                   /id="PRO_0000051103"
FT   REPEAT          50..90
FT                   /note="WD 1"
FT   REPEAT          174..213
FT                   /note="WD 2"
FT   REPEAT          228..266
FT                   /note="WD 3"
FT   REPEAT          270..308
FT                   /note="WD 4"
FT   REPEAT          310..349
FT                   /note="WD 5"
FT   REGION          528..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          423..476
FT                   /evidence="ECO:0000255"
FT   COILED          512..589
FT                   /evidence="ECO:0000255"
FT   COILED          640..673
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        528..548
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..665
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        666..688
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         475
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         481
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
FT   MOD_RES         514
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BSC4"
SQ   SEQUENCE   688 AA;  80238 MW;  F097D7EF0F0E84D8 CRC64;
     MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKDVDVR RRIELIQDFE MPTVCTTIKV
     SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF EILSDDYSKI VFLHNDRYIE
     FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY FVGASSEVYR LNLEQGRYLN PLQTDAAENN
     VCDINTVHGL FATGTIEGRV ECWDPRVRKR VGVLDCALNS VTADSEINSL PTISALKFNG
     ALSMAVGTST GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLVLSA DSRIVKMWNK
     DSGKIFTSLE PEHDLNDVCL YPSSGMILTA NESPKMGIYY IPVLGPAPRW CSFLDNLTEE
     LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH GFFMDIRLYH KVKLMVNPFA
     YEEYRKDKIR QKIEETRAQR VQLKKLPKVN KELALKLIEE EEEKQKSTLK KKVKSLPNIL
     TDDRFKVMFE NPDFQVDEDS EEFRLLNPLV SRISEKRKKQ LRLLEQQEQL KNEEEEEPEG
     KPSDAESSES SDDEKDWVEE VRKQRRLLQQ EERVKRQEQL KEDQQTVLKP QFYEIKAGEE
     FRSFKESATK QKLMNKTLED RLKLEAKHGT LSVSDTTVGS KQLTFTLKRS EQQKKQQEAE
     KLHRQERKKL RRSASHLRSR PRRGRPFH