NOL10_SCHPO
ID NOL10_SCHPO Reviewed; 634 AA.
AC O74879;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Ribosome biogenesis protein enp2 homolog;
GN Name=enp2; ORFNames=SPCC330.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-531, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May be involved in rRNA-processing and ribosome biosynthesis.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the 90S pre-ribosomes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20914.1; -; Genomic_DNA.
DR PIR; T41319; T41319.
DR RefSeq; NP_587709.1; NM_001022704.2.
DR AlphaFoldDB; O74879; -.
DR SMR; O74879; -.
DR BioGRID; 275571; 4.
DR IntAct; O74879; 1.
DR MINT; O74879; -.
DR STRING; 4896.SPCC330.09.1; -.
DR iPTMnet; O74879; -.
DR MaxQB; O74879; -.
DR PaxDb; O74879; -.
DR PRIDE; O74879; -.
DR EnsemblFungi; SPCC330.09.1; SPCC330.09.1:pep; SPCC330.09.
DR GeneID; 2538997; -.
DR KEGG; spo:SPCC330.09; -.
DR PomBase; SPCC330.09; enp2.
DR VEuPathDB; FungiDB:SPCC330.09; -.
DR eggNOG; KOG2321; Eukaryota.
DR HOGENOM; CLU_009923_0_0_1; -.
DR InParanoid; O74879; -.
DR OMA; GEWVMST; -.
DR PhylomeDB; O74879; -.
DR PRO; PR:O74879; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0030686; C:90S preribosome; ISO:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR040382; NOL10/Enp2.
DR InterPro; IPR012580; NUC153.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14927; PTHR14927; 1.
DR Pfam; PF08159; NUC153; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis;
KW rRNA processing; WD repeat.
FT CHAIN 1..634
FT /note="Ribosome biogenesis protein enp2 homolog"
FT /id="PRO_0000337683"
FT REPEAT 51..91
FT /note="WD 1"
FT REPEAT 182..221
FT /note="WD 2"
FT REPEAT 235..274
FT /note="WD 3"
FT REPEAT 278..320
FT /note="WD 4"
FT REGION 513..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 531
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 634 AA; 72239 MW; 42D3C50CD0A9DC71 CRC64;
MSLKVQNPNN VRVYTVSGEG VTQRLPNWIS KRKLKKDYAL SHRIELLQDF EYPEASNRIK
CTRDGKYAMA TGVYKPHIKV FDFAEMSLKF ERHTDAENVQ FEILSDDWTK SVHLQTDRTV
DFHSQGGIHY STRIPKYGRD LKYHYPNCDL YLAAAGDEVY RLNLEQGRFL NPLKIESAQI
DSPTGGVNVI DINPMHQLLA FGTDAGSVEF WDPRDRSRVG ILEIPSTVPS TPYSDNSRSV
TALKYRNDGL NVAIGLSDGA TLLYDLRSSS PYMSKDQGYS MPIKSLHWMD SALDGTARVL
SADSKIIKIW EKDTGKPFSS IEPTVELNDV CPIEGTGLIL TANEGSPMHA FYIPSLNPAP
RWCSFLDNIT EEMEENPAPT IYDDYKFVTK KELLNLGLDH LVGTGVIRAY MHGFFIDNNL
YEKARLIANP FSYEEHRQKI VKERLEKQRA SKIRSQNRPK VNAGLASRLS YQENKLRKKT
GVTDGPSILE DERFKNVFTD KEFEVDEDTL EYKQLHPSRS EARGLTAAEE SEEEKEHTKG
IKFSSDEESL SDMEEENETF DALVDRRKTE QQVSNEKTPQ ETIRSTPSGM EMTFKVEKKK
KSKPVNRDED STSGKKKQVT QGRRSASKNV FRNM
