ID   NOL11_BOVIN             Reviewed;         718 AA.
AC   Q3MHH2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Nucleolar protein 11;
GN   Name=NOL11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. May be required for both optimal
CC       rDNA transcription and small subunit (SSU) pre-rRNA processing at sites
CC       A', A0, 1 and 2b (By similarity). {ECO:0000250|UniProtKB:Q9H8H0}.
CC   -!- SUBUNIT: Interacts with UTP4. Interacts with FBL/fibrillarin in a
CC       transcription-dependent manner. May associate with the proposed t-UTP
CC       subcomplex of the SSU processome containing at least UTP4, WDR43,
CC       HEATR1, UTP15, WDR75. {ECO:0000250|UniProtKB:Q9H8H0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H8H0}.
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DR   EMBL; BC105239; AAI05240.1; -; mRNA.
DR   RefSeq; NP_001029697.1; NM_001034525.1.
DR   AlphaFoldDB; Q3MHH2; -.
DR   SMR; Q3MHH2; -.
DR   STRING; 9913.ENSBTAP00000021210; -.
DR   PaxDb; Q3MHH2; -.
DR   PRIDE; Q3MHH2; -.
DR   Ensembl; ENSBTAT00000021210; ENSBTAP00000021210; ENSBTAG00000015951.
DR   GeneID; 517743; -.
DR   KEGG; bta:517743; -.
DR   CTD; 25926; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015951; -.
DR   VGNC; VGNC:32155; NOL11.
DR   eggNOG; ENOG502SB74; Eukaryota.
DR   GeneTree; ENSGT00390000009760; -.
DR   HOGENOM; CLU_025196_0_0_1; -.
DR   InParanoid; Q3MHH2; -.
DR   OMA; DTEKNQR; -.
DR   OrthoDB; 570601at2759; -.
DR   TreeFam; TF325877; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000015951; Expressed in spermatid and 106 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0034455; C:t-UTP complex; ISS:UniProtKB.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISS:UniProtKB.
DR   GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; ISS:UniProtKB.
DR   InterPro; IPR042859; NOL11.
DR   InterPro; IPR012584; NUC205.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15633; PTHR15633; 1.
DR   Pfam; PF08168; NUC205; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Activator; Methylation; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing; Transcription; Transcription regulation.
FT   CHAIN           1..718
FT                   /note="Nucleolar protein 11"
FT                   /id="PRO_0000256834"
FT   MOD_RES         346
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8H0"
SQ   SEQUENCE   718 AA;  80290 MW;  7BC589CB1594D1EB CRC64;
     MADLEEGFAL TAVPLGSGPD GPLGVEQSGK TDQFLVTDSG RTVILYKVSD QKPLGSWSVK
     QGQIITCPAV CNFQTGEYIV VHDNKVLRIW NNEDVNLDKV FKATLSAEVY RIHSIQGTEP
     LVLFKEGAVR GLEALLAEPQ QKIETVISDE EVIKWTKFFM VFRHPVLIFI TEKHGNYFVY
     VQKFNSRILS KYTLLLGQEE KCVIQSFSTS VGRKFISLMS LSSDGCVYET LIPIHPSEPE
     KNQRLVQSQL LKSVVSGSAR NGVALAILDQ DHIAVLGAPL PASKECLSVW NTKFQTLQTS
     KELPQGTSGQ LWYYGENLFM LHGKFLTVVP FKCEVSSLAG ALGKLKHSQD PGIHATPHFV
     NWETSQGCGL GSQNSEQSKR ILRRRKVEVS VQPEVPASTQ LLATIQKDSE KHIEVELRKF
     LATKRTPDFH TIIGDVIIGL LGRCKAEPSF YPCNCLMQLV QTHVLSYSLC PGLMEFALEK
     TDVQILQLCL QQFPDIPESV TCACLKVFLS IGDDTLQDTD INMESVSDYM DPVQDGEMEE
     QTAFLQNGFS PEEDNCDSCA QKLKEKPQAA ADESTSCPVT PKRAALLNAV LHSAYSETFL
     LPHLKDIPAQ HSTLFLQYLY FLYLKCSENA TMTLPGTHPP TLSQIMDWIC LLLDANFTVV
     VMIPEAKRLL LSLYKFVKSQ ISICSELNKI EVSFRELQKL NQEKNNRELY SIEVLELF