NOL11_MOUSE
ID NOL11_MOUSE Reviewed; 723 AA.
AC Q8BJW5; Q8BGJ1; Q8R3Q3; Q99KA5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Nucleolar protein 11;
GN Name=Nol11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, Mesonephros, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Ribosome biogenesis factor. May be required for both optimal
CC rDNA transcription and small subunit (SSU) pre-rRNA processing at sites
CC A', A0, 1 and 2b (By similarity). {ECO:0000250|UniProtKB:Q9H8H0}.
CC -!- SUBUNIT: Interacts with UTP4. Interacts with FBL/fibrillarin in a
CC transcription-dependent manner. May associate with the proposed t-UTP
CC subcomplex of the SSU processome containing at least UTP4, WDR43,
CC HEATR1, UTP15, WDR75. {ECO:0000250|UniProtKB:Q9H8H0}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9H8H0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJW5-2; Sequence=VSP_015459;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
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DR EMBL; AK038696; BAC30102.1; -; mRNA.
DR EMBL; AK076704; BAC36450.1; -; mRNA.
DR EMBL; AK078524; BAC37323.1; -; mRNA.
DR EMBL; BC004785; AAH04785.1; -; mRNA.
DR EMBL; BC024874; AAH24874.1; -; mRNA.
DR CCDS; CCDS25566.1; -. [Q8BJW5-1]
DR CCDS; CCDS48965.1; -. [Q8BJW5-2]
DR RefSeq; NP_001154801.1; NM_001161329.1. [Q8BJW5-2]
DR RefSeq; NP_598463.2; NM_133702.2. [Q8BJW5-1]
DR AlphaFoldDB; Q8BJW5; -.
DR SMR; Q8BJW5; -.
DR BioGRID; 213155; 1.
DR STRING; 10090.ENSMUSP00000102368; -.
DR PhosphoSitePlus; Q8BJW5; -.
DR EPD; Q8BJW5; -.
DR MaxQB; Q8BJW5; -.
DR PaxDb; Q8BJW5; -.
DR PeptideAtlas; Q8BJW5; -.
DR PRIDE; Q8BJW5; -.
DR ProteomicsDB; 293871; -. [Q8BJW5-1]
DR ProteomicsDB; 293872; -. [Q8BJW5-2]
DR Antibodypedia; 19207; 36 antibodies from 17 providers.
DR DNASU; 68979; -.
DR Ensembl; ENSMUST00000018577; ENSMUSP00000018577; ENSMUSG00000018433. [Q8BJW5-1]
DR Ensembl; ENSMUST00000106757; ENSMUSP00000102368; ENSMUSG00000018433. [Q8BJW5-2]
DR GeneID; 68979; -.
DR KEGG; mmu:68979; -.
DR UCSC; uc007mah.2; mouse. [Q8BJW5-1]
DR UCSC; uc007maj.2; mouse. [Q8BJW5-2]
DR CTD; 25926; -.
DR MGI; MGI:1916229; Nol11.
DR VEuPathDB; HostDB:ENSMUSG00000018433; -.
DR eggNOG; ENOG502SB74; Eukaryota.
DR GeneTree; ENSGT00390000009760; -.
DR HOGENOM; CLU_025196_0_0_1; -.
DR InParanoid; Q8BJW5; -.
DR OMA; DTEKNQR; -.
DR OrthoDB; 570601at2759; -.
DR PhylomeDB; Q8BJW5; -.
DR TreeFam; TF325877; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 68979; 28 hits in 74 CRISPR screens.
DR ChiTaRS; Nol11; mouse.
DR PRO; PR:Q8BJW5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BJW5; protein.
DR Bgee; ENSMUSG00000018433; Expressed in dorsal pancreas and 254 other tissues.
DR Genevisible; Q8BJW5; MM.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0034455; C:t-UTP complex; ISS:UniProtKB.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISS:UniProtKB.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; ISS:UniProtKB.
DR InterPro; IPR042859; NOL11.
DR InterPro; IPR012584; NUC205.
DR PANTHER; PTHR15633; PTHR15633; 1.
DR Pfam; PF08168; NUC205; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Methylation; Nucleus; Reference proteome;
KW Ribosome biogenesis; rRNA processing; Transcription;
KW Transcription regulation.
FT CHAIN 1..723
FT /note="Nucleolar protein 11"
FT /id="PRO_0000096932"
FT REGION 549..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 346
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9H8H0"
FT VAR_SEQ 508..527
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_015459"
FT CONFLICT 145
FT /note="S -> A (in Ref. 2; AAH24874)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="V -> T (in Ref. 2; AAH24874)"
FT /evidence="ECO:0000305"
FT CONFLICT 462
FT /note="V -> E (in Ref. 2; AAH04785/AAH24874)"
FT /evidence="ECO:0000305"
FT CONFLICT 522
FT /note="E -> K (in Ref. 2; AAH24874)"
FT /evidence="ECO:0000305"
FT CONFLICT 565
FT /note="D -> N (in Ref. 2; AAH04785/AAH24874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 723 AA; 80818 MW; 2693F0730B683447 CRC64;
MATLEEEFTL STGVLGAGPE GFLGVEQTDK ADQFLVTDSG RTVVLYKVSD QKPLGSWSVK
QGQSITCPAV CNFQTGEYIM VHDHKVLRIW NNDDVNVDKV FKATLSAEVH RIHSVQRTEP
LVLFRGGAAR GLEALLVEPQ QNIESVIPDE EVIVWSEVFM LFKQPVLIFI TENHGHYYAY
VRLCKSHSLS KYTLLLEKEE KSVKPNFTAR VDGKFISLVS LSSDGCIYET LIPIYSSDTE
QNQRLVRALM LKSVVSGGVR NGVALTILDQ DHIAVLGPPL SASKECLSIW NIKFQTLQTS
KELPQGTSGQ LWYHGEVLFM LHGKSLTVIP YKCEESSLAG ALGKLKHTQE SGTHSVPHFV
NWETCSGYEL GSSGAEQSRT LRRKKVETNL QPEVPGFKQL LSIIKKDSEK HIEVELRKFL
AKSTPAFHTI IGDLVAGLVG RCKAEPSFYP RNCLTQLIQT HVLSYSLCPD LMEIALEHTD
VQMLQLCLQQ FPDIPESTTC ACLKLFLSVG DDCLRDSNIN MESVFDYSDS TQDEKKEMEE
QIEIVQNGFG PEDGNCSEDS QQLNDKPADT AHEPGSFPVT SCPVAPKRAA LLNAVLHSAY
SEPFLLPHLK DIPAKHVTLF LQYLYFLYLK CTGSATMTLP GVNPPTVSQI MDWICLLLDA
NFTVLLMIPE AKRLLLILYN FVKSQISIYS ELNKIAVSFR ELQRLNREKS SRGLYSIEVL
ELF
