ID   NOL11_PONAB             Reviewed;         718 AA.
AC   Q5RB52;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Nucleolar protein 11;
GN   Name=NOL11;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. May be required for both optimal
CC       rDNA transcription and small subunit (SSU) pre-rRNA processing at sites
CC       A', A0, 1 and 2b (By similarity). {ECO:0000250|UniProtKB:Q9H8H0}.
CC   -!- SUBUNIT: Interacts with UTP4. Interacts with FBL/fibrillarin in a
CC       transcription-dependent manner. May associate with the proposed t-UTP
CC       subcomplex of the SSU processome containing at least UTP4, WDR43,
CC       HEATR1, UTP15, WDR75. {ECO:0000250|UniProtKB:Q9H8H0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H8H0}.
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DR   EMBL; CR858803; CAH91008.1; -; mRNA.
DR   RefSeq; NP_001125582.1; NM_001132110.1.
DR   AlphaFoldDB; Q5RB52; -.
DR   SMR; Q5RB52; -.
DR   STRING; 9601.ENSPPYP00000009622; -.
DR   GeneID; 100172497; -.
DR   KEGG; pon:100172497; -.
DR   CTD; 25926; -.
DR   eggNOG; ENOG502SB74; Eukaryota.
DR   InParanoid; Q5RB52; -.
DR   OrthoDB; 570601at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0034455; C:t-UTP complex; ISS:UniProtKB.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISS:UniProtKB.
DR   GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; ISS:UniProtKB.
DR   InterPro; IPR042859; NOL11.
DR   InterPro; IPR012584; NUC205.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15633; PTHR15633; 1.
DR   Pfam; PF08168; NUC205; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Activator; Methylation; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing; Transcription; Transcription regulation.
FT   CHAIN           1..718
FT                   /note="Nucleolar protein 11"
FT                   /id="PRO_0000096933"
FT   MOD_RES         346
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8H0"
SQ   SEQUENCE   718 AA;  81119 MW;  9D7FC4A2B9CC6F6F CRC64;
     MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD QKPLGSWSVK
     QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV FKATLSAEVY RILSVQGTEP
     LVLFKEGAVR GLEALLADPQ QKIETVISDE EVIKWTKFFI VFRHRVLIFI TEKHGNYFAY
     VQMFNSRILT KYTLLLGQDE NSVVESFTAS VDRKFISLMS LSSDGCIYET LIPIRPTDPE
     KNQSLVRSLL LKAVVSDNTQ NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS
     KELSQGTSGQ VWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD PGTHVVPHFV
     NWETPQGCGL GFQNSEQSRR ILRRRKTEVS LQPEVPPSKQ LLSTIMKDSE KHIEVEVRKF
     LALKQTPDFH TVVGDTVTGL LERCKAEPSF YPRNCLMQLI QTHVLSYSLC PDLMEIALKK
     KDVQLLQLCL QQFPDIPESV TCACLKIFLS IGDDSLQETD VSMESVFDYS NSVHDEKMEE
     QTEILQNGFN PEEDKCNNCD QELNKKPQDE TKESTSCPVV QKRAALLNAI LHSAFSETFL
     LPHLKDIPAQ HITLFLKYLY FLYLKCSENA TMTLPGIHPP TLNQIMDWIC LLLDANFTVV
     VMMPEAKRLL INLYKLVKSQ ITVYSELNKI EVSFRELQKL NQEKNNRGLY SIEVLELF